Microvascular endothelial function and cognitive performance: The ELSA-Brasil cohort study

Vascular Medicine
Luisa C C BrantSandhi Maria Barreto

Abstract

Impaired microvascular endothelial function may be implicated in the etiology of cognitive decline. Yet, current data on this association are inconsistent. Our objective is to investigate the relation of microvascular endothelial function to cognitive performance in the ELSA-Brasil cohort study. A total of 1521 participants from ELSA-Brasil free of dementia underwent peripheral arterial tonometry (PAT) to quantify microvascular endothelial function (PAT-ratio and mean baseline pulse amplitude (BPA)) and cognitive tests that covered the domains of memory, verbal fluency, and executive function at baseline. Cognitive tests in participants aged 55 years old and above were repeated during the second examination (mean follow-up: 3.5 (0.3) years). Linear regression and generalized linear models were used to evaluate the association between endothelial function, global cognitive performance, and performance on specific cognitive domains. In unadjusted cross-sectional analyses, we found that BPA and PAT-ratio were associated with worse global cognitive performance (mean difference for BPA: -0.07, 95% CI: -0.11; -0.03, p<0.01; mean difference for PAT-ratio: 0.11, 95% CI: 0.01; 0.20, p=0.02), worse performance on learning, recall, and wo...Continue Reading

References

Feb 17, 1998·Statistics in Medicine·J K Lindsey, B Jones
May 15, 2009·Journal of Epidemiology and Community Health·M ElovainioA Singh-Manoux
May 27, 2009·Trends in Cardiovascular Medicine·Naomi M Hamburg, Emelia J Benjamin
Apr 17, 2010·Journal of the American College of Cardiology·Yasushi MatsuzawaHisao Ogawa
May 10, 2011·Circulation. Cardiovascular Imaging·Renate B SchnabelThomas Münzel
Jul 23, 2011·Stroke; a Journal of Cerebral Circulation·Philip B GorelickUNKNOWN American Heart Association Stroke Council, Council on Epidemiology and Prevention, Council on Cardiovascular Nursing, Counci
Sep 29, 2011·Annual Review of Psychology·Ian J Deary
Jan 12, 2012·American Journal of Epidemiology·Estela M L AquinoMoyses Szklo
Aug 8, 2012·Circulation·Andreas J FlammerAmir Lerman
Aug 14, 2012·Journal of the Neurological Sciences·Raj N KalariaMasafumi Ihara
Oct 30, 2012·Stroke; a Journal of Cerebral Circulation·Carrington R WendellAlan B Zonderman
Jan 12, 2013·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Martin PrinceCleusa P Ferri
May 1, 2011·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Nina B SilverbergTanis J Ferman
Jun 12, 2013·Journal of Hypertension·Luisa C C BrantAntônio L P Ribeiro
Nov 28, 2013·Journal of the American Heart Association·Yasushi MatsuzawaHisao Ogawa
Mar 4, 2014·International Journal of Epidemiology·Maria Inês SchmidtIsabela M Bensenor
May 3, 2014·São Paulo Medical Journal = Revista Paulista De Medicina·Valéria Maria de Azeredo PassosSandhi Maria Barreto
Aug 26, 2014·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Daniel BosM Arfan Ikram
Feb 18, 2015·Nature Reviews. Neurology·Niels D Prins, Philip Scheltens
Nov 17, 2015·Psychosomatic Medicine·Melanie R NaibergBenjamin I Goldstein
Dec 8, 2015·Journal of Alzheimer's Disease : JAD·Shir Lynn LimTze Pin Ng
Oct 1, 2013·Dementia & Neuropsychologia·Juliana Alves BatistaValéria Maria de Azeredo Passos

❮ Previous
Next ❯

Citations

Aug 11, 2018·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Patrick J SmithAndrew Sherwood

❮ Previous
Next ❯

Software Mentioned

Stata

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.