Microvascular flow dictates the compromise between spatial resolution and acquisition time in Ultrasound Localization Microscopy

Scientific Reports
Vincent HingotOlivier Couture

Abstract

Medical ultrasound is a widely used diagnostic imaging technique for tissues and blood vessels. However, its spatial resolution is limited to a sub-millimeter scale. Ultrasound Localization Microscopy was recently introduced to overcome this limit and relies on subwavelength localization and tracking of microbubbles injected in the blood circulation. Yet, as microbubbles follow blood flow, long acquisition time are required to detect them in the smallest vessels, leading to long reconstruction of the microvasculature. The objective of this work is to understand how blood flow limits acquisition time. We studied the reconstruction of a coronal slice of a rat's brain during a continuous microbubble injection close to clinical concentrations. After acquiring 192000 frames over 4 minutes, we find that the biggest vessels can be reconstructed in seconds but that it would take tens of minutes to map the entire capillary network. Moreover, the appropriate characterization of flow profiles based on microbubble velocity within vessels is bound by even more stringent temporal limitations. As we use simple blood flow models to characterize its impact on reconstruction time, we foresee that these results and methods can be adapted to deter...Continue Reading

References

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Dec 16, 2016·Physics in Medicine and Biology·Yann DesaillyOlivier Couture
Feb 9, 2017·Ultrasonics·Vincent HingotOlivier Couture
Oct 24, 2017·Scientific Reports·Josquin FoiretKatherine W Ferrara
Feb 2, 2018·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Pengfei SongShigao Chen
Jul 12, 2018·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Olivier CoutureMickael Tanter

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Citations

Jan 14, 2021·Biomedical Physics & Engineering Express·David EspíndolaGianmarco Pinton
Mar 17, 2021·Nature Biomedical Engineering·Charlie DemenéFabienne Perren
Mar 18, 2021·Neuroscience·Baptiste HeilesDavid Maresca
Jan 25, 2020·Ultrasound in Medicine & Biology·Kirsten Christensen-JeffriesRuud J G van Sloun
Mar 25, 2021·Physics in Medicine and Biology·Erwan HardyJean Provost
Jul 24, 2021·NeuroImage. Clinical·Jérôme BarangerJulien Aguet
Oct 1, 2021·Physics in Medicine and Biology·Jingyi YinJue Zhang

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