Microvascular fractal dimension predicts prognosis and response to chemotherapy in glioblastoma: an automatic image analysis study

Laboratory Investigation; a Journal of Technical Methods and Pathology
Cong ChenYi-Fang Ping

Abstract

The microvascular profile has been included in the WHO glioma grading criteria. Nevertheless, microvessels in gliomas of the same WHO grade, e.g., WHO IV glioblastoma (GBM), exhibit heterogeneous and polymorphic morphology, whose possible clinical significance remains to be determined. In this study, we employed a fractal geometry-derived parameter, microvascular fractal dimension (mvFD), to quantify microvessel complexity and developed a home-made macro in Image J software to automatically determine mvFD from the microvessel-stained immunohistochemical images of GBM. We found that mvFD effectively quantified the morphological complexity of GBM microvasculature. Furthermore, high mvFD favored the survival of GBM patients as an independent prognostic indicator and predicted a better response to chemotherapy of GBM patients. When investigating the underlying relations between mvFD and tumor growth by deploying Ki67/mvFD as an index for microvasculature-normalized tumor proliferation, we discovered an inverse correlation between mvFD and Ki67/mvFD. Furthermore, mvFD inversely correlated with the expressions of a glycolytic marker, LDHA, which indicated poor prognosis of GBM patients. Conclusively, we developed an automatic approac...Continue Reading

References

Mar 14, 2001·Journal of Neuro-oncology·R D Folkerth
Sep 15, 2001·British Journal of Cancer·J G EdwardsK J O'Byrne
Jun 20, 2002·Journal of the National Cancer Institute·Lynn HlatkyJudah Folkman
Feb 24, 1956·Science·O WARBURG
Nov 10, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Robert L CampDavid L Rimm
Mar 11, 2005·The New England Journal of Medicine·Monika E HegiRoger Stupp
Mar 25, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Reinhold NafeBerthold Schneider
Feb 4, 2006·Cell Death and Differentiation·A EramoR De Maria
Jun 19, 2007·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Matthias T WyssUlrich Roelcke
Feb 21, 2009·The New England Journal of Medicine·Hai YanDarell D Bigner
May 23, 2009·Science·Matthew G Vander HeidenCraig B Thompson
May 7, 2010·CA: a Cancer Journal for Clinicians·Erwin G Van MeirJeffrey J Olson
May 7, 2010·Breast Cancer Research and Treatment·Ndeke NyirendaV Krishnan Ramanujan
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
May 20, 2011·Nature·Peter Carmeliet, Rakesh K Jain
Oct 21, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Yuan-Yuan ZhaoLi Zhang
Nov 2, 2011·Laboratory Investigation; a Journal of Technical Methods and Pathology·Vladimir V IakovlevGeorge M Yousef
Mar 23, 2012·Breast Cancer Research and Treatment·Karine MahéoCaroline Goupille
Aug 18, 2012·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Mitko VetaPaul J van Diest
Aug 22, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ashley M LaughneyWendy A Wells
Aug 25, 2012·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Vani J A KondaIrving Waxman
Sep 19, 2012·Proceedings of the National Academy of Sciences of the United States of America·Mariano BarbieriMario Nicodemi
Oct 3, 2012·Cancer Research·Prakash ChinnaiyanRobert Gillies
Aug 21, 2013·Nature Medicine·Kyrre E EmblemA Gregory Sorensen
Oct 23, 2014·Cancer Biomarkers : Section a of Disease Markers·Juan HuangLei Liu
Jul 15, 2015·Nature Reviews. Clinical Oncology·Frances E LennonRavi Salgia
Aug 14, 2015·Brain Pathology·Cara J ValvonaGeoffrey J Pilkington
Oct 21, 2015·Journal of the National Comprehensive Cancer Network : JNCCN·Louis Burt NaborsAnita M Engh
Oct 24, 2015·Virchows Archiv : an International Journal of Pathology·Henrik O HelinJorma Isola
Oct 29, 2015·International Journal of Cancer. Journal International Du Cancer·Rikke Løvendahl EefsenMartin Illemann
Nov 19, 2015·Proceedings of the National Academy of Sciences of the United States of America·Sara M TolaneyRakesh K Jain

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Citations

Oct 28, 2019·Clinical Pharmacokinetics·Belén P SolansIñaki F Trocóniz
Jan 26, 2020·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Guolan LuEben L Rosenthal
Jan 13, 2021·Scientific Reports·Abbas GhasemiXianguo Li
Jul 8, 2021·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Luca PasquiniAlessandro Bozzao
Nov 10, 2021·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Jintao ChenZhi-Xiong Lin

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Methods Mentioned

BETA
surgical resection
imaging techniques

Software Mentioned

GraphPad
GraphPad Prism
Image J
tile
PASW Statistics
REMBRANDT

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