Microvascular function at the margins of early experimental myocardial infarcts in isolated rabbit hearts

Heart and Vessels
M D Sage, J B Gavin

Abstract

Injection of low-viscosity resin was used to identify in situ functional blood vessels at the margins of developing regional myocardial infarcts. The ventral interventricular branch (VIB) of the left coronary artery was occluded for 0-240 min in 20 isolated perfused rabbit hearts. After perfusion fixation with glutaraldehyde, resin was injected into the coronary arteries--that injected into the VIB contained dispersed lead dioxide and that injected into the remainder of the heart contained Fat Red 7B dye. This allowed macroscopic and microscopic identification of functional blood vessels. Following transmural freeze fracture, left ventricles were examined using back-scattered electron imaging in a scanning electron microscope. Close to 60% of capillaries in nonischemic myocardium allowed the passage of resin. Thirty minutes of ischemia produced a hyperemic increase to 80%-90% in the proportion of filled vessels. After 60 min, however, a severe reperfusion defect corresponding to the "no-reflow" phenomenon had developed, with virtually all vessels collapsed and less than 10% functional. Among the structurally normal myocytes adjacent to the infarct margin there was a significant reduction (to 30%-40%) in the proportion of functi...Continue Reading

References

Feb 1, 1979·Cardiovascular Research·F L Belloni
Mar 5, 1976·Virchows Archiv. A, Pathological Anatomy and Histology·J P CamilleriA Carpentier
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Feb 1, 1984·The Anatomical Record·M D Sage, J B Gavin
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Jul 1, 1959·The Journal of Pathology and Bacteriology·H L SHEEHAN, J C DAVIS

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Citations

Aug 18, 2006·Basic Research in Cardiology·Thorsten Reffelmann, Robert A Kloner
Apr 1, 1995·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·P A ReddyF E Hossler
Dec 1, 1991·Journal of Electron Microscopy Technique·J B GavinM D Sage

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