Abstract
Hantavirus nephropathy (HVN) is an uncommon etiology of acute renal failure due to hantavirus infection. Pathological features suggestive of HVN historically reported are medullary interstitial hemorrhages in a background of acute interstitial nephritis (AIN). However, interstitial hemorrhages may be lacking because of medullary sampling error. This emphasizes that other pathological criteria may be of interest. We performed a retrospective clinicopathological study of 17 serologically proven HVN cases with renal biopsy from 2 nephrology centers in northern France. Histologic analysis was completed by immunohistochemistry with anti-CD3, anti-CD68, and anti-CD34 antibodies. Three control groups were not related to hantavirus infection: acute tubular necrosis (ATN) of ischemic or toxic etiology and AIN were used for comparison. Renal biopsy analysis showed that almost all HVN cases with medullary sampling (9/10) displayed interstitial hemorrhages, whereas focal hemorrhages were detected in 2 of the 7 "cortex-only" specimens. ATN was common, as it was present in 15 (88.2%) of 17 HVN cases. By contrast, interstitial inflammation was scarce with no inflammation or only slight inflammation, representing 15 (88.2%) of 17 cases. Moreov...Continue Reading
References
Mar 1, 1978·The Journal of Infectious Diseases·H W LeeK M Johnson
Jul 1, 1974·Kidney International·K SolezR H Heptinstall
Jan 1, 1996·Clinical Immunology and Immunopathology·M TemonenH Holthöfer
Nov 27, 2001·Nephron·J MustonenA Pasternack
Dec 4, 2003·The Lancet Infectious Diseases·Jan ClementMarc Van Ranst
Jun 29, 2004·Archives of Virology·M NiikuraS Morikawa
Apr 28, 2006·Kidney International·M H MiettinenJ T Mustonen
Sep 19, 2006·Virus Research·Daisuke HayasakaMasanori Terajima
Jan 19, 2008·The American Journal of Pathology·Yingjian LiYouhua Liu
Feb 26, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·K SolezM Valente
Jul 25, 2008·Journal of the American Society of Nephrology : JASN·Dusan Ferluga, Alenka Vizjak
Jun 27, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Anja Grosse LordemannJan U Becker
Jul 19, 2011·Clinical Nephrology·M L TroxellD C Houghton
Jul 22, 2011·Journal of Virology·Ellen KrautkrämerMartin Zeier
Jul 5, 2012·Reviews in Medical Virology·Antti VaheriOlli Vapalahti
Aug 13, 2013·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Maja Martinuč BergočJernej Pajek
Sep 11, 2013·Nature Reviews. Microbiology·Antti VaheriJukka Mustonen
Jun 24, 2014·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Christopher BoehlkeElke Neumann-Haefelin
Citations
Jan 23, 2016·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Lu-Xi ZouLing Sun
Jan 5, 2017·Infectious Diseases·Jukka MustonenSatu Mäkelä
Jun 12, 2019·Viruses·Miriam MaasBarry Rockx
Jan 26, 2020·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Juliet SchurderAlexandre Hertig
Aug 2, 2017·Infectious Diseases·Tuula K OutinenJukka Mustonen
Jun 1, 2018·Nephron Extra·Markus MeierMartin Nitschke
Aug 1, 2020·Pathogens·Paula MantulaTuula Outinen