Microvascular Perfusion Changes following Transarterial Hepatic Tumor Embolization

Journal of Vascular and Interventional Radiology : JVIR
Carmen Gacchina JohnsonMatthew R Dreher

Abstract

To quantify changes in tumor microvascular (< 1 mm) perfusion relative to commonly used angiographic endpoints. Rabbit Vx2 liver tumors were embolized with 100-300-μm LC Bead particles to endpoints of substasis or complete stasis (controls were not embolized). Microvascular perfusion was evaluated by delivering two different fluorophore-conjugated perfusion markers (ie, lectins) through the catheter before embolization and 5 min after reaching the desired angiographic endpoint. Tumor microvasculature was labeled with an anti-CD31 antibody and analyzed with fluorescence microscopy for perfusion marker overlap/mismatch. Data were analyzed by analysis of variance and post hoc test (n = 3-5 per group; 18 total). Mean microvascular density was 70 vessels/mm(2) ± 17 (standard error of the mean), and 81% ± 1 of microvasculature (ie, CD31(+) structures) was functionally perfused within viable Vx2 tumor regions. Embolization to the extent of substasis eliminated perfusion in 37% ± 9 of perfused microvessels (P > .05 vs baseline), whereas embolization to the extent of angiographic stasis eliminated perfusion in 56% ± 8 of perfused microvessels. Persistent microvascular perfusion following embolization was predominantly found in the tumor...Continue Reading

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Citations

Dec 18, 2015·Journal of Materials Science. Materials in Medicine·Andrew L LewisBradford J Wood
Jan 25, 2018·AJR. American Journal of Roentgenology·Stacy K Y FanMehran Midia
Jul 12, 2019·Frontiers in Oncology·Kaio Murilo Monteiro EspíndolaMarta Chagas Monteiro
Nov 23, 2016·Cardiovascular and Interventional Radiology·Luke R WilkinsJohn R Haaga
Jan 23, 2021·Expert Opinion on Drug Delivery·Andrew S MikhailBradford J Wood
Mar 8, 2021·Journal of Vascular and Interventional Radiology : JVIR·Suvranu GanguliMichael C Soulen
Sep 7, 2018·Bioconjugate Chemistry·Sakkarapalayam M MahalingamPhilip S Low

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