PMID: 6411639Jun 1, 1983Paper

Microvascular response in cancellous bone to halothane-induced hypotension in pigs

International Journal of Oral Surgery
S HellemG E Nilsson

Abstract

The microvascular response in cancellous bone to halothane-induced hypotension was studied simultaneously using Laser Doppler Flowmetry (LDF) and clearance of locally injected 133Xe in the subapical mandibular bone of 16 young pigs. During halothane inhalation, a significant reduction in mean blood pressure to values ranging from 22 to 60 mm Hg was observed. The blood flow, as measured with LDF, increased in more than 60% of the animals with hypotension levels above 30 mm Hg. At hypotension levels below 30 mm Hg, blood flow decreased in all cases. The individual regional vascular resistance, calculated as the quotient between blood pressure and recorded blood flow value, was significantly reduced (p less than 0.001) during hypotension. Rhythmical flow variations, observed in some animals at normotension, disappeared immediately following the start of halothane inhalation, but returned when blood pressure was stabilized at a lower level. For recordings made with 133Xe-clearance, a significant reduction (p less than 0.001) in the logarithmic decay of the washout curves was observed during hypotension. This logarithmic decay was correlated to the reduced blood pressure levels (r = 0.73). No average change in regional vascular resi...Continue Reading

References

Jan 1, 1976·Anesthesia and Analgesia·D J MiletichE D McKissic
Oct 1, 1972·Anesthesiology·D E Longnecker, P D Harris
Jan 1, 1969·Acta Anaesthesiologica Scandinavica·L Westermark
May 1, 1970·Anesthesiology·E I EgerC E Whitcher
Oct 1, 1980·IEEE Transactions on Bio-medical Engineering·G E NilssonP A Oberg

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Citations

Jul 1, 1993·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·G S LaustenB Dahl
Jan 1, 1986·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·M F SwiontkowskiB A Rahn
Aug 1, 1991·Acta Orthopaedica Scandinavica·J Vegter, P J Klopper
Dec 1, 2013·Bone Research·Ryan E Tomlinson, Matthew J Silva

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