Microvascular testicular blood flow as evaluated by laser Doppler flowmetry after the surgical induction of varicocele

Archives of Andrology
N SalamaJ E Damber

Abstract

This study was conducted to evaluate the changes in microvascular testicular blood flow (microvascular TBF), which may be associated with varicocele. The pathology was developed through partial ligation of left renal vein in 4 groups of rats. Controls of each group underwent sham surgery. It was observed that microvascular TBF dropped and its vasomotion became inhibited once the left renal vein was partially ligated as studied by laser Doppler flowmetry (LDF). Four to five minutes later, blood flow rose to the pretreatment level and that of controls. Vasomotion reappeared with a uniform frequency and amplitude. At different periods of varicocele bearing (1, 3, 6, and 14 weeks) microvascular TBF was reevaluated. Vasomotion appeared intact without any abnormalities in the 4 groups. To examine the response of testicular microvasculature after surgical creation of the varicocele to pharmacological stimulation another group of animals received human chorionic gonadotropin (hCG) treatment 6 weeks after varicocele creation. Vasomotion was inhibited in these animals. In conclusion, LDF is a suitable tool to evaluate microvascular TBF in vivo. It can detect acute changes in blood flow that may happen at surgical induction of varicocele....Continue Reading

References

May 1, 1976·Biology of Reproduction·M J FreeR A Jaffe
Nov 1, 1977·Acta Physiologica Scandinavica·J E Damber, P O Janson
Aug 1, 1971·Fertility and Sterility·L Dubin, R D Amelar
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Jan 1, 1980·Annual Review of Physiology·B R Duling, B Klitzman
Feb 1, 1980·Pflügers Archiv : European journal of physiology·P Eggert, C Weiss
Mar 1, 1981·Microvascular Research·M Intaglietta

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