Microvasculature alters the dispersion properties of shear waves--a multi-frequency MR elastography study

NMR in Biomedicine
Lauriane JugéRalph Sinkus

Abstract

Magnetic Resonance Elastography (MRE) uses macroscopic shear wave propagation to quantify mechanical properties of soft tissues. Micro-obstacles are capable of affecting the macroscopic dispersion properties of shear waves. Since disease or therapy can change the mechanical integrity and organization of vascular structures, MRE should be able to sense these changes if blood vessels represent a source for wave scattering. To verify this, MRE was performed to quantify alteration of the shear wave speed cs due to the presence of vascular outgrowths using an aortic ring model. Eighteen fragments of rat aorta included in a Matrigel matrix (n=6 without outgrowths, n=6 with a radial outgrowth extent of ~600 µm and n=6 with ~850 µm) were imaged using a 7 Tesla MR scanner (Bruker, PharmaScan). High resolution anatomical images were acquired in addition to multi-frequency MRE (ν = 100, 115, 125, 135 and 150 Hz). Average cs was measured within a ring of ~900 µm thickness encompassing the aorta and were normalized to cs0 of the corresponding Matrigel. The frequency dependence was fit to the power law model cs ~ν(y). After scanning, optical microscopy was performed to visualize outgrowths. Results demonstrated that in presence of vascular o...Continue Reading

References

Dec 16, 1992·Journal of the National Cancer Institute·N WeidnerG Gasparini
Jan 3, 1991·The New England Journal of Medicine·N WeidnerJ Folkman
Nov 1, 1989·Acta Pathologica Japonica·S KawasakiM Awai
May 1, 1987·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·M SatoR M Nerem
Mar 24, 1999·Journal of the National Cancer Institute·K JamesP Therasse
Oct 5, 2001·Clinical Radiology·M G HarisinghaniP R Mueller
Dec 20, 2003·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Ben FabryJeffrey J Fredberg
Apr 19, 2005·Magnetic Resonance Imaging·Ralph SinkusMathias Fink
Oct 31, 2007·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Ralph SinkusMathias Fink
May 7, 2008·NMR in Biomedicine·Michael A GreenRalph Sinkus
Jul 31, 2008·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Patrick AsbachIngolf Sack
Sep 6, 2008·Methods in Enzymology·Alfred C AplinRoberto F Nicosia
Dec 23, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E A EisenhauerJ Verweij
Jun 2, 2009·Journal of Structural Biology·Shauheen S SoofiChristopher J Murphy
Sep 4, 2009·Journal of Cellular and Molecular Medicine·R F Nicosia
Jan 12, 2010·The Journal of the Acoustical Society of America·Sverre Holm, Ralph Sinkus
Feb 18, 2010·Proteomics·Chris S HughesGilles A Lajoie
Feb 23, 2010·Seminars in Liver Disease·Riccardo Lencioni, Josep M Llovet
Jul 2, 2010·Journal of Oncology·Paloma Sanz-CamenoRicardo Moreno-Otero
Mar 24, 2011·Physics in Medicine and Biology·E H ClaytonP V Bayly
Mar 20, 2012·Journal of Hepatology·UNKNOWN European Association For The Study Of The Liver, UNKNOWN European Organisation For Research And Treatment Of Cancer
May 11, 2012·European Radiology·Philippe GarteiserBernard E Van Beers
Mar 21, 2013·Muscle & Nerve·Laëtitia DebernardSabine F Bensamoun
Jun 27, 2013·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Kay M PepinKiaran P McGee

❮ Previous
Next ❯

Citations

Apr 30, 2016·Journal of Biomechanics·Alice C PongLynne E Bilston
Feb 6, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Stefan HetzerIngolf Sack
Nov 13, 2020·NMR in Biomedicine·Pilar Sango SolanasOlivier Beuf
Feb 23, 2021·NeuroImage·Lucy V HiscoxCurtis L Johnson
Apr 4, 2021·International Journal of Molecular Sciences·Louise Orcheston-FindlayGeraldine O'Neill

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.