PMID: 490690Oct 1, 1979Paper

Microvasculature in hypertrophic scars and the effects of pressure

The Journal of Trauma
C W Kischer, M R Shetlar

Abstract

The fine structure of the microvasculature was compared among eight samples of normal skin, 79 granulation tissues, 48 hypertrophic scars, 11 hypertrophic scars treated with mechanical pressure, and 13 mature scars. Increased synthesis activity is suggested in endothelial cells from granulation tissues, is less in hypertrophic scars, and low in mature scars. In hypertrophic scars most of the microvessels appear partially or completely occluded. Endothelial cell nuclei are crenated, many villous projections from the endothelial cell membranes exist on the blood side, and endothelial cell junctions are often complex, although no large gaps are observed. In all the granulation tissues studied fibrin polymer is present, occurring intraluminally and interstitially, which may be related to endothelial cell proliferation. Therapeutic mechanical pressure over 1 to 3 months effects striking changes in endothelial and perivascular satellite cells. Rented areas appear in endothelial cell cytoplasm. A few such areas were found in cases of nontreated hypertrophic scars but in no other group. Pressure-treated scars also demonstrate degenerating perivascular satellite cells, which also are observed in a few cases of mature scars but in no oth...Continue Reading

Citations

Apr 1, 1985·British Journal of Plastic Surgery·R B BerryM E Hackett
Mar 15, 2003·Clinics in Plastic Surgery·Shahrad R Rahban, Warren L Garner
Jan 1, 1986·Experimental Pathology·P D Kittlick
Feb 14, 1998·Plastic and Reconstructive Surgery·H GieleF Wood
Apr 18, 2007·Journal of Burn Care & Research : Official Publication of the American Burn Association·Youfu XieLoren H Engrav
May 1, 1996·Neuroradiology·J W Van GoethemA M De Schepper
Apr 2, 2014·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·JieXing ZhengXi-Qiao Wang
Aug 31, 2000·Microvascular Research·A B Baker, J E Sanders
Jul 16, 2015·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Emily C LynamXiQiao Wang
Jan 1, 1984·The Journal of Hand Surgery·C W Kischer, D P Speer
Jun 8, 2000·Annals of the New York Academy of Sciences·E E Tredget
Nov 27, 2007·Burns : Journal of the International Society for Burn Injuries·Amélie BourgetE Patricia Egerszegi
Sep 24, 2005·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Elodie LepaultChristine L Theoret
May 8, 2014·International Wound Journal·Qing ChunWang XiQiao
Jan 1, 1986·The Journal of Dermatologic Surgery and Oncology·L A Brown, H E Pierce
Oct 3, 2003·Pathology, Research and Practice·Thaís AmadeuAndréa Costa
Jun 1, 1997·The Surgical Clinics of North America·E E TredgetA Ghahary
Jan 1, 1994·Burns : Journal of the International Society for Burn Injuries·T A BransR W Kreis
Jun 21, 2005·Annales de chirurgie plastique et esthétique·F LhoestO Heymans
Feb 16, 2015·Burns : Journal of the International Society for Burn Injuries·Cecilia W P Li-TsangKwok-Kuen Cheung
Dec 1, 1992·Burns : Journal of the International Society for Burn Injuries·P Dziewulski
Dec 24, 2016·Journal of Burn Care & Research : Official Publication of the American Burn Association·Bonnie C CarneyJeffrey W Shupp
Mar 31, 2000·Journal of Prosthodontics : Official Journal of the American College of Prosthodontists·B A BradfordR L Englemeier
Mar 26, 2021·American Journal of Veterinary Research·Claudia L ReynerAnne A Wooldridge
Jun 1, 1991·Burns : Journal of the International Society for Burn Injuries·S D LinC S Lai

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.