PMID: 2499979Jan 1, 1989Paper

Microvasculature in the small portal tracts in idiopathic portal hypertension. A morphological comparison with other hepatic diseases

Virchows Archiv. A, Pathological Anatomy and Histopathology
T TeradaY Nakanuma

Abstract

The morphology of the microvasculature in the small portal tracts was examined in normal livers, idiopathic portal hypertension (IPH) and other hepatic diseases. The microvasculature examined was arbitrary divided into two groups: that near the limiting plate and that within portal tracts, particularly around bile ducts. Based on comparisons of histology, immunohistochemistry and vascular casts, it is suggested that the former corresponded to inlet venules and the latter to distributing portal veins and peribiliary capillary plexus. Both of these microvasculatures were positive for Ulex europaeus lectin I, and (infrequently and weakly) for factor VIII-related antigen. Morphometry disclosed that inlet venules were reduced in number in IPH compared with normal livers and that distributing portal veins, peribiliary capillary plexus and inlet venules were increased in extrahepatic portal obstruction, chronic active hepatitis and extrahepatic obstructive cholestasis. We believe that the change in the microvasculature reflects abnormal microcirculation in the small portal tracts, and that the reduction of inlet venules plays an important role in the development of portal hypertension in IPH.

References

Apr 1, 1979·Archivum Histologicum Japonicum = Nihon Soshikigaku Kiroku·O Ohtani
Jan 1, 1988·Virchows Archiv. A, Pathological Anatomy and Histopathology·T TeradaY Nakanuma
Nov 1, 1974·Archivum Histologicum Japonicum = Nihon Soshikigaku Kiroku·T MurakamiY Shimada
Apr 1, 1981·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S M HsuH Fanger

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Citations

May 7, 2005·Clinical Rheumatology·Hiroyuki KogawaHiromi Ishibashi
Jun 1, 2010·Pathology Oncology Research : POR·Tadashi Terada, Toshiaki Moriki
Jun 4, 2010·Pathology International·Tadashi Terada, Toshiaki Moriki
Feb 24, 2001·Journal of the American Veterinary Medical Association·S E BunchJ M Cullen
Jan 1, 1997·The Tohoku Journal of Experimental Medicine·T TeradaY Nakanuma
Nov 25, 2014·Virchows Archiv : an International Journal of Pathology·M Isabel FielThomas D Schiano
May 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J HaratakeA Horie
Aug 22, 2018·Histopathology·Maria GuidoUNKNOWN International Liver Pathology Study Group
Sep 15, 2005·The American Journal of Surgical Pathology·Alyssa M KrasinskasEmma E Furth
Apr 13, 2018·Virchows Archiv : an International Journal of Pathology·Maria GuidoGuido Colloredo

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