PMID: 7940132May 1, 1994Paper

Microvasculature of the anterior optic nerve

Survey of Ophthalmology
G A Cioffi, E M Van Buskirk

Abstract

The traditional definition of glaucoma as a disorder of increased intraocular pressure (IOP) oversimplifies the clinical situation. Some glaucoma patients never have higher than normal IOP and others continue to develop optic nerve damage despite maximal lowering of IOP. Another possible factor in the etiology of glaucoma may be regulation of the regional microvasculature of the anterior optic nerve. One reason to believe that microvascular factors are important is that many microvascular diseases are associated with glaucomatous optic neuropathy. In this study, endothelin-1 was used to produce vasoconstriction of the ocular vasculature following both intravitreal and perineural delivery. Intravitreal injections (1.25 and 2.50 micrograms) were given to six rabbits to assess the vascular response of the posterior segment. In addition, endothelin (0.0-4.2 micrograms) was delivered with an osmotically driven minipump system to the perineural region of six rabbits. Vasoconstriction of the anterior optic nerve vasculature was observed following both methods of endothelin delivery. A better understanding of the microvasculature of the anterior optic nerve is needed to evaluate its relationship to glaucomatous damage. Modulation of th...Continue Reading

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Citations

May 30, 2001·Survey of Ophthalmology·G A Cioffi
Jun 23, 1998·Survey of Ophthalmology·A HarrisG A Cioffi
Sep 5, 2002·Progress in Retinal and Eye Research·Leonard A Levin, Lynn K Gordon
Mar 24, 2000·The British Journal of Ophthalmology·A B Cullinane, P E Cleary
Jan 10, 2012·The British Journal of Ophthalmology·Mari HiraokaMasahiko Takada
Jul 1, 1995·American Journal of Ophthalmology·E OndaE M Van Buskirk
Aug 17, 2010·Experimental Eye Research·John C MorrisonElaine C Johnson
Dec 22, 2004·Progress in Retinal and Eye Research·John C MorrisonLijun Jia
Sep 1, 2007·Clinical & Experimental Ophthalmology·Zeynep AktaşBerati Hasanreisoğlu
Nov 15, 2012·Expert Opinion on Therapeutic Patents·Andrea ScozzafavaClaudiu T Supuran
Aug 19, 2007·Journal of Glaucoma·Iok-Hou Pang, Abbot F Clark
Feb 19, 2015·Japanese Journal of Ophthalmology·Steven L Bernstein, Neil R Miller
Dec 4, 2019·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Joseph F Rizzo
Jan 1, 1997·Acta Ophthalmologica Scandinavica. Supplement·R A Hitchings

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