PMID: 7940132May 1, 1994Paper

Microvasculature of the anterior optic nerve

Survey of Ophthalmology
G A Cioffi, E M Van Buskirk


The traditional definition of glaucoma as a disorder of increased intraocular pressure (IOP) oversimplifies the clinical situation. Some glaucoma patients never have higher than normal IOP and others continue to develop optic nerve damage despite maximal lowering of IOP. Another possible factor in the etiology of glaucoma may be regulation of the regional microvasculature of the anterior optic nerve. One reason to believe that microvascular factors are important is that many microvascular diseases are associated with glaucomatous optic neuropathy. In this study, endothelin-1 was used to produce vasoconstriction of the ocular vasculature following both intravitreal and perineural delivery. Intravitreal injections (1.25 and 2.50 micrograms) were given to six rabbits to assess the vascular response of the posterior segment. In addition, endothelin (0.0-4.2 micrograms) was delivered with an osmotically driven minipump system to the perineural region of six rabbits. Vasoconstriction of the anterior optic nerve vasculature was observed following both methods of endothelin delivery. A better understanding of the microvasculature of the anterior optic nerve is needed to evaluate its relationship to glaucomatous damage. Modulation of th...Continue Reading


Aug 1, 1976·American Journal of Ophthalmology·D R Anderson, S Braverman
Nov 1, 1977·Archives of Ophthalmology·B SchwartzS L Fishbein
Sep 1, 1976·American Journal of Ophthalmology·M F LiebermanW R Green
Apr 15, 1992·American Journal of Ophthalmology·E M Van Buskirk, G A Cioffi
May 1, 1991·Archives of Ophthalmology·M W MacCumberS H Snyder
May 15, 1990·American Journal of Ophthalmology·E M Van BuskirkW H Fahrenbach
Sep 1, 1988·Journal of Electron Microscopy Technique·W H FahrenbachE M Van Buskirk
May 1, 1987·Archives of Ophthalmology·S Yoneya, M O Tso
Jul 1, 1985·Archives of Ophthalmology·H A QuigleyE M Addicks
Sep 1, 1970·American Journal of Ophthalmology·D R Anderson
Feb 1, 1983·International Ophthalmology·A BillK Ujiie
Dec 1, 1984·Ophthalmology·J E GrunwaldB L Petrig
May 1, 1980·American Journal of Ophthalmology·L M ParverD O Carpenter
Apr 15, 1996·Microscopy Research and Technique·J C MorrisonE M Van Buskirk
Sep 1, 1952·The British Journal of Ophthalmology·N ASHTON
Jul 1, 1994·Journal of Glaucoma·K SugiyamaE M Van Buskirk

❮ Previous
Next ❯


May 30, 2001·Survey of Ophthalmology·G A Cioffi
Jun 23, 1998·Survey of Ophthalmology·A HarrisG A Cioffi
Sep 5, 2002·Progress in Retinal and Eye Research·Leonard A Levin, Lynn K Gordon
Mar 24, 2000·The British Journal of Ophthalmology·A B Cullinane, P E Cleary
Jan 10, 2012·The British Journal of Ophthalmology·Mari HiraokaMasahiko Takada
Jul 1, 1995·American Journal of Ophthalmology·E OndaE M Van Buskirk
Aug 17, 2010·Experimental Eye Research·John C MorrisonElaine C Johnson
Dec 22, 2004·Progress in Retinal and Eye Research·John C MorrisonLijun Jia
Sep 1, 2007·Clinical & Experimental Ophthalmology·Zeynep AktaşBerati Hasanreisoğlu
Nov 15, 2012·Expert Opinion on Therapeutic Patents·Andrea ScozzafavaClaudiu T Supuran
Aug 19, 2007·Journal of Glaucoma·Iok-Hou Pang, Abbot F Clark
Feb 19, 2015·Japanese Journal of Ophthalmology·Steven L Bernstein, Neil R Miller
Dec 4, 2019·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Joseph F Rizzo
Jan 1, 1997·Acta Ophthalmologica Scandinavica. Supplement·R A Hitchings

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.