Abstract
Dermatomyositis and vasculitic neuropathies are disorders with immune mediated ischemic injuries. Cellular responses to hypoxia include the hypoxia-inducible factor-1 (HIF-1)-induced transcription of genes involved in angiogenesis. To study their possible roles in those disorders, the immunohistochemical expression of HIF-1alpha, HIF-1beta, HIF-2alpha, vascular endothelial growth factor (VEGF), VEGF-receptor (VEGF-R) and erythropoietin-receptor was investigated. Cases of normal nerves, diabetic neuropathy, normal muscles, polymyositis and inclusion-body-myositis served as controls. The latter were chosen because they represent comparable inflammatory disorders, however, in these ischemia/hypoxia is not supposed to play such a prominent pathogenetic role. Hypoxia-related proteins were not detected in normal controls. In polymyositis and inclusion-body-myositis, there was VEGF-R-expression in muscle fibers and HIF-2alpha reactivity in endothelial cells. In dermatomyositis, HIF-1alpha and HIF-1beta were found in endothelial cells, whereas HIF-2alpha, erythropoietin-receptor, VEGF and VEGF-R additionally were observed in muscle fibers. In vasculitic and diabetic neuropathies, a variable focal expression of hypoxia-inducible factors...Continue Reading
References
Mar 1, 1989·Annals of Neurology·J T KisselJ R Mendell
Jun 6, 1995·Proceedings of the National Academy of Sciences of the United States of America·G L WangG L Semenza
May 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·G L Wang, G L Semenza
Apr 1, 1993·Acta Neurologica Scandinavica·A EngelhardtB Neundörfer
Jan 1, 1997·Genes & Development·H TianD W Russell
Mar 4, 1998·Neurology·H SatoiJ Kimura
Feb 17, 1999·The British Journal of Dermatology·K KikuchiK Tamaki
Aug 3, 1999·Circulation·T K RosengartR G Crystal
Feb 8, 2000·Biological Chemistry·P ScheideggerR Jaussi
Mar 4, 2000·The New England Journal of Medicine·S H LeeP A Thistlethwaite
Jul 7, 2000·Muscle & Nerve·D HeussB Neundörfer
Sep 12, 2000·Neurology·M P CollinsJ T Kissel
Nov 22, 2001·Experimental Neurology·A HökeD W Zochodne
Mar 22, 2002·Pflügers Archiv : European journal of physiology·T HoferM Gassmann
Jul 20, 2002·Proceedings of the National Academy of Sciences of the United States of America·Anna K JunkDaniel M Rosenbaum
Jan 11, 2003·Arthritis and Rheumatism·I MarieH Courtois
Feb 18, 2003·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·H G Augustin
Feb 22, 2003·Gene Therapy·T A KhanR J Laham
Sep 27, 2003·Lancet·Marinos C Dalakas, Reinhard Hohlfeld
Sep 16, 2004·Current Opinion in Neurology·Marinos C Dalakas
Mar 7, 2007·Journal of Clinical Immunology·Jozélio Freire CarvalhoYehuda Shoenfeld
Oct 12, 2007·Neurology·Steven A Greenberg
Nov 21, 2007·Neurology·Reinhard Hohlfeld, Klaus Dornmair
Sep 30, 2008·Arthritis and Rheumatism·Cecilia GrundtmanIngrid E Lundberg
Nov 14, 2008·Internal Medicine Journal·V S LimayeP J Roberts-Thomson
Citations
Nov 14, 2012·Annals of the Rheumatic Diseases·Mei ZongHåkan Westerblad
May 2, 2012·Arthritis Research & Therapy·William ColeyKanneboyina Nagaraju
Aug 15, 2013·Arthritis Research & Therapy·Li Alemo MuntersHelene Alexanderson
Jan 19, 2016·Clinical Reviews in Allergy & Immunology·Angela CeribelliCarlo Selmi
Aug 13, 2015·Acta Neuropathologica·Eroboghene E Ubogu
May 28, 2011·Diabetes·Manjusha PandeEva L Feldman
Apr 29, 2016·Acta Neuropathologica Communications·Corinna PreußeWerner Stenzel
Apr 7, 2011·Nature Reviews. Rheumatology·Mei Zong, Ingrid E Lundberg
Sep 25, 2017·Arthritis & Rheumatology·Cyril GitiauxBénédicte Chazaud
Sep 6, 2020·Current Opinion in Rheumatology·Marta Loredo MartinezMariele Gatto
Aug 19, 2017·Scientific Reports·Noemí De LunaEduard Gallardo