Microvasculopathic neuromuscular diseases: lessons from hypoxia-inducible factors

Neuromuscular Disorders : NMD
Stefan Probst-CousinDieter Heuss

Abstract

Dermatomyositis and vasculitic neuropathies are disorders with immune mediated ischemic injuries. Cellular responses to hypoxia include the hypoxia-inducible factor-1 (HIF-1)-induced transcription of genes involved in angiogenesis. To study their possible roles in those disorders, the immunohistochemical expression of HIF-1alpha, HIF-1beta, HIF-2alpha, vascular endothelial growth factor (VEGF), VEGF-receptor (VEGF-R) and erythropoietin-receptor was investigated. Cases of normal nerves, diabetic neuropathy, normal muscles, polymyositis and inclusion-body-myositis served as controls. The latter were chosen because they represent comparable inflammatory disorders, however, in these ischemia/hypoxia is not supposed to play such a prominent pathogenetic role. Hypoxia-related proteins were not detected in normal controls. In polymyositis and inclusion-body-myositis, there was VEGF-R-expression in muscle fibers and HIF-2alpha reactivity in endothelial cells. In dermatomyositis, HIF-1alpha and HIF-1beta were found in endothelial cells, whereas HIF-2alpha, erythropoietin-receptor, VEGF and VEGF-R additionally were observed in muscle fibers. In vasculitic and diabetic neuropathies, a variable focal expression of hypoxia-inducible factors...Continue Reading

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Nov 14, 2012·Annals of the Rheumatic Diseases·Mei ZongHåkan Westerblad
May 2, 2012·Arthritis Research & Therapy·William ColeyKanneboyina Nagaraju
Jan 19, 2016·Clinical Reviews in Allergy & Immunology·Angela CeribelliCarlo Selmi
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Aug 19, 2017·Scientific Reports·Noemí De LunaEduard Gallardo

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