Microvesicles in haemoglobinopathies offer insights into mechanisms of hypercoagulability, haemolysis and the effects of therapy

British Journal of Haematology
Maxwell WestermanJohn Porter

Abstract

Levels of circulating red blood cell (RBC)-derived vesicles are increased in sickle cell anaemia (SCA) and thalassaemia intermedia (TI) but the mechanisms, effects and controlling factors may differ. This study found that levels of vesicles and intravascular haemolysis were linked as shown by the correlation between levels of vesicles and plasma Hb. Vesicle levels were 6-fold greater in SCA and 4-fold greater in TI than in controls. The proportion of plasma Hb within vesicles was increased in SCA and TI with a significantly higher proportion in TI. We examined whether subpopulations of RBC expressing phosphatidylserine (PS) were a source of PS(+) vesicles and observed a significant association. Thrombin generation was promoted by the vesicles in which 40-50% expressed PS. In TI, markers of thrombin generation were significantly related to PS(+) RBC. Splenectomy in TI had significant effects including greater increases in vesicle levels, plasma Hb, PS(+) RBCs and thrombin generation markers than in unsplenectomised patients. In hydroxycarbamide (HC)-treated SCA patients these measures were decreased compared with untreated controls. The relationship between vesicle levels and plasma Hb suggests a mechanism linking vesiculation t...Continue Reading

References

Apr 12, 1990·The New England Journal of Medicine·G P RodgersA W Nienhuis
Aug 1, 1986·The British Journal of Surgery·N JacksonM A Hughes
Aug 1, 1971·American Journal of Clinical Pathology·H N NaumannB J Williams
Apr 1, 1984·British Journal of Haematology·M P WestermanK Wu
Dec 16, 1997·Proceedings of the National Academy of Sciences of the United States of America·D W KnowlesJ A Chasis
Dec 21, 2000·British Journal of Haematology·M D CappelliniA P Mannucci
Nov 12, 2002·Nature Medicine·Christopher D ReiterMark T Gladwin
Sep 5, 2003·International Journal of Hematology·Vichai AtichartakarnKatcharin Aryurachai
Dec 30, 2003·Cytometry. Part B, Clinical Cytometry·Kovit PattanapanyasatH Kyle Webster
Jun 30, 2005·Blood·Vikki G NolanMartin H Steinberg
Aug 27, 2005·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Giel J C G M BosmanJan M Werre
Oct 19, 2006·Free Radical Biology & Medicine·Anne JeffersDaniel B Kim-Shapiro

❮ Previous
Next ❯

Citations

Feb 26, 2013·Journal of Thrombosis and Thrombolysis·Rakhi P NaikSophie Lanzkron
May 5, 2010·Immunology and Cell Biology·Ricardo F AntunesFernando A Arosa
Nov 21, 2008·The New England Journal of Medicine·Mark T Gladwin, Elliott Vichinsky
Oct 22, 2010·Current Opinion in Hematology·Jean-Daniel TissotGiorgia Canellini
Jun 27, 2013·Transfusion Medicine and Hemotherapy : Offizielles Organ Der Deutschen Gesellschaft Fur̈ Transfusionsmedizin Und Immunham̈atologie·Olivier RubinJean-Daniel Tissot
Jul 29, 2009·Blood·Shelley E Crary, George R Buchanan
Mar 5, 2014·Hematology/oncology Clinics of North America·Frans A Kuypers
Nov 26, 2013·Clinics in Chest Medicine·Roberto F Machado, Harrison W Farber
May 11, 2011·The Journal of Sexual Medicine·Gregory J Kato
May 20, 2011·Blood Cells, Molecules & Diseases·Sumanta BasuAbhijit Chakrabarti
Aug 19, 2015·Redox Biology·S VoskouM Kleanthous
Jul 25, 2015·British Journal of Haematology·Imane AgoutiIsabelle Thuret
Apr 19, 2011·Transfusion·Daniel B Kim-ShapiroMark T Gladwin
Nov 5, 2011·American Journal of Hematology·Denis F NoubouossieAnne Demulder
Apr 15, 2014·Transfusion·Daniel R Ambruso
Dec 18, 2013·European Journal of Haematology·Vichai AtichartakarnKatcharin Aryurachai
Dec 5, 2009·British Journal of Haematology·Gregory J Kato, James G Taylor
Jul 31, 2013·Transfusion·Elliott VichinskyUNKNOWN CDC Thalassemia Investigators
Apr 15, 2015·Journal of Veterinary Internal Medicine·L KiddN Mackman
Dec 10, 2014·Blood Cells, Molecules & Diseases·Antonella MeloniJohn C Wood
Jun 11, 2016·Blood Cells, Molecules & Diseases·Maxwell Westerman, John B Porter
Nov 10, 2013·Oxidative Medicine and Cellular Longevity·Lucia De FranceschiFranco Turrini
Jun 30, 2012·La Presse médicale·Laurent SavaleFlorence Parent
Apr 23, 2014·Free Radical Biology & Medicine·Michael Craig LarsonNeil Hogg
May 3, 2016·British Journal of Haematology·Robert P Hebbel, Nigel S Key
Oct 10, 2014·PLoS Computational Biology·Roy MalkaJohn M Higgins

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.