Microvessel density and p53 overexpression in young women with breast cancer: a case-control study

Clinical Breast Cancer
B KalfonJ A Sparano

Abstract

Several reports have indicated that young women (less than 40 years of age) with breast cancer have a worse prognosis than older women. We performed a case-control study in order to confirm this observation and to determine whether this was attributable to increased microvessel density (MVD) or p53 expression. Twenty-six young women (cases) with stage I-III breast cancer that had adequate paraffin-embedded archival tissue were identified by the Montefiore Medical Center Tumor Registry over a 24-year period. For each case, two or three control subjects at least 40 years of age or older were selected from the registry and matched for nodal status and tumor size. Immunohistochemistry was performed for MVD and p53 overexpression. A Cox proportional hazard model was performed to examine the influence of age, MVD, p53 overexpression, and recognized prognostic factors on disease-free and overall survival. There were 26 cases (median age, 36 years) and 72 controls (median age, 64 years). The groups were well matched for known prognostic variables. There was no significant difference in p53 overexpression or MVD in the cases and controls. In multivariate analysis, the only features associated with an increased risk of recurrence include...Continue Reading

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Citations

Sep 25, 2010·Journal of American College Health : J of ACH·Kanayo Umeh, Leonnie Jones
Jun 24, 2010·The Breast : Official Journal of the European Society of Mastology·Peeter KarihtalaArja Jukkola-Vuorinen

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