PMID: 25735375Mar 5, 2015Paper

Microvessel density as a prognostic factor in ovarian cancer: a systematic review and meta-analysis

Asian Pacific Journal of Cancer Prevention : APJCP
Lei HeXia Zhao

Abstract

The prognostic value of microvessel density (MVD), reflecting angiogenesis, detected in ovarian cancer is currently controversial. Here we performed a meta-analysis of all relevant eligible studies. A comprehensive search of online PubMed, Medline, EMBASE and Sciencedirect was performed to identify all related articles. The search strategy was designed as 'microvessel density', 'ovarian cancer', 'ovarian neoplasm', 'CD34' and 'angiogenesis'. The studies were categorized by author/year, number of patients, FIGO stage, histology, cutoff value for microvessel density, types of survival analysis, methods of hazard rations (HR) estimation, HR and its 95% confidence interval (CI). Combined hazard ratios suggested that high MVD was associated with poor overall survival (OS) and progression-free survival (PFS), with HR and 95% CIs of 1.84 (1.33-2.35) and 1.36 (1.06-1.66), respectively. Subgroup analysis showed that high MVD detected by CD34 was relevant for OS [HR=1.67 (1.36-2.35)], but not MVD detected with other antibodies [HR=2.11 (0.90-3.31)]. Another subgroup analysis indicated that high MVD in patients without pre-chemotherapy, but not with pre- chemotherapy, was associated with OS [HR=1.88(1.59-2.18 and HR=1.70 (-0.18-3.59)]. Th...Continue Reading

References

Dec 16, 1992·Journal of the National Cancer Institute·N WeidnerG Gasparini
Nov 18, 1971·The New England Journal of Medicine·J Folkman
Jun 21, 1996·International Journal of Cancer. Journal International Du Cancer·G GaspariniP Bevilacqua
Apr 17, 1997·Nature·W Risau
Mar 31, 2000·Nature Medicine·P Carmeliet
Sep 23, 2000·Nature·G D YancopoulosJ Holash
Sep 23, 2000·Nature·P Carmeliet, R K Jain
Mar 10, 2001·Journal of the National Cancer Institute·W D BeeckenY Shing
Jul 21, 2001·Cancer Letters·K NakayamaM Fukumoto
Jul 28, 2001·BMJ : British Medical Journal·D G Altman
Jan 29, 2002·Lancet·David A Grimes, Kenneth F Schulz
Jun 20, 2002·Journal of the National Cancer Institute·Lynn HlatkyJudah Folkman
Aug 3, 2002·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·K HataK Miyazaki
Sep 14, 2004·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·M R RaspolliniG L Taddei
May 18, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Michael J GoodheartRichard E Buller
Sep 22, 2005·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·M R RaspolliniG L Taddei
Oct 3, 2006·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·C TaskiranH Guner
Apr 24, 2007·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Kirsi A SuhonenVeli-Matti Kosma
Sep 22, 2007·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Julia E PalmerTerence P Rollason
May 23, 2009·Nature Reviews. Cancer·Robert C BastGordon B Mills
May 31, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Helen BarracloughRamaswamy Govindan
Jan 24, 2012·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Ping LiuHua Meng
Aug 21, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Hong-Ling PengXia Zhao
Jan 16, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Jia-Ying LinBing-De Yin
Sep 3, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Li-Na LiJun Yan

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Citations

May 2, 2016·Cancer Letters·Zhongyue LuoShengtao Zhou
Oct 27, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ruixia XieDekui Zhang
Aug 29, 2016·International Journal of Clinical Oncology·S Krishna PriyaT S Ganesan
Dec 31, 2015·World Journal of Gastroenterology : WJG·Lei WangPing Dong
Oct 16, 2020·Biochimica Et Biophysica Acta. Reviews on Cancer·Bahar Yetkin-ArikCornelis J F van Noorden
Mar 25, 2018·Veterinary Immunology and Immunopathology·Adnan FayyadChristina Puff

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