PMID: 6109758Jan 1, 1981Paper

Microvessels isolated from rat brain: localization of astrocyte processes by immunohistochemical techniques

Journal of Neurochemistry
F P WhiteM D Norenberg

Abstract

Microvascular networks were isolated from rat telencephalon by density gradient centrifugation. The vessels prepared were characterized morphologically at the light and electron microscope level and immunohistochemically by the localization of glutamine synthetase and glial fibrillary acidic protein, two proteins found almost exclusively in astrocytes. The vast majority of the vessels prepared contained more than just endothelial cells surrounded by a basement membrane. Many arterioles were found still retaining their smooth muscle cells. Pericytes were found in association with most of the venules and many of the capillaries. Astrocyte processes remained attached to most of the microvessels. These results show that vessels prepared from rat brain still maintain most of their complex intercellular contacts and must be viewed as a heterogeneous network of cells.

References

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Citations

Apr 15, 1985·Experientia·H KobayashiM Trabucchi
Aug 6, 1986·Brain Research·T MichalakG R Dutton
Jan 1, 1985·Neurochemistry International·M W Bradbury
Jul 1, 1997·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·W M Pardridge
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Dec 17, 2009·Journal of Neuropathology and Experimental Neurology·Gerald D SilverbergConrad E Johanson
Jan 11, 2002·Neurological Research·Frantisek St'astnýDaniela Jezová
Sep 1, 2006·Analytical Biochemistry·Martin BubikGert Fricker
Jun 15, 1982·Biochemical and Biophysical Research Communications·B S Inasi, I R Brown
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Nov 1, 1995·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·V MoroF Lasbennes
Sep 1, 1991·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·E Galea, C Estrada
Dec 9, 2010·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Nadia A Scott, Timothy H Murphy
Nov 20, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Jian Yi LiWilliam M Pardridge
Mar 1, 1993·Journal of Neurochemistry·J Brownlees, C H Williams
May 1, 1987·Journal of Neurochemistry·F P White, S R White
Dec 11, 1992·Pharmaceutisch Weekblad. Scientific Edition·J B Van BreeD D Breimer

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