Microviscometry reveals reduced blood viscosity and altered shear rate and shear stress profiles in microvessels after hemodilution

Proceedings of the National Academy of Sciences of the United States of America
David S LongE R Damiano

Abstract

We show that many salient hemodynamic flow properties, which have been difficult or impossible to assess in microvessels in vivo, can be estimated by using microviscometry and fluorescent microparticle image velocimetry in microvessels >20 microm in diameter. Radial distributions in blood viscosity, shear stress, and shear rate are obtained and used to predict axial pressure gradient, apparent viscosity, and endothelial-cell surface-layer thickness in vivo. Based solely on microparticle image velocimetry data, which are readily obtainable during the course of most intravital microscopy protocols from systemically injected particle tracers, we show that the microviscometric method consistently predicted a reduction in local and apparent blood viscosity after isovolemic hemodilution. Among its clinical applications, hemodilution is a procedure that is used to treat various pathologies that require reduction in peripheral vascular-flow resistance. Our results are directly relevant in this context because they suggest that the fractional decrease in systemic hematocrit is approximately 25-35% greater than the accompanying fractional decrease in microvascular-flow resistance in vivo. In terms of its fundamental usefulness, the micro...Continue Reading

References

Nov 1, 1973·Microvascular Research·R J Jendrucko, J S Lee
Jan 1, 1966·Journal of Applied Physiology·S ChienM I Gregersen
Nov 1, 1994·Circulation Research·A R PriesP Gaehtgens
Sep 28, 2000·Pflügers Archiv : European journal of physiology·A R PriesP Gaehtgens
Aug 31, 2001·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·K E Norman
Feb 28, 2002·Biophysical Journal·Edward R Damiano, Thomas M Stace

❮ Previous
Next ❯

Citations

Aug 10, 2006·Journal of Mathematical Biology·Wensheng Zhang, Aurélie Edwards
Jan 20, 2007·Annals of Biomedical Engineering·Xuewen ChenDov Jaron
May 30, 2009·Annals of Biomedical Engineering·Dimitri Gidaspow, Jing Huang
Sep 17, 2009·Annals of Biomedical Engineering·Hyoungsu BaekGeorge Em Karniadakis
Jul 24, 2010·Annals of Biomedical Engineering·Bumseok NamgungSangho Kim
Apr 6, 2012·Annals of Biomedical Engineering·Bingmei M Fu, Yang Liu
Mar 8, 2008·Medical & Biological Engineering & Computing·Robert S Reneman, Arnold P G Hoeks
Feb 24, 2009·Nature Medicine·Markus MoserReinhard Fässler
Aug 13, 2008·The Journal of Experimental Medicine·Anil K ChauhanDenisa D Wagner
Apr 30, 2009·Journal of the Royal Society, Interface·C PoelmaJ Westerweel
Dec 22, 2009·Journal of the Royal Society, Interface·H BaekG E Karniadakis
Mar 22, 2007·Annual Review of Biomedical Engineering·Sheldon WeinbaumEdward R Damiano
Jan 1, 2005·Annual Review of Fluid Mechanics·Aleksander S Popel, Paul C Johnson
Apr 17, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Krishna SriramMarcos Intaglietta
Mar 30, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Peng Kai OngSangho Kim
Dec 23, 2011·Biochemistry Research International·Alexander V Maksimenko, Askar D Turashev
May 16, 2009·Circulation Research·Daniel R PotterEdward R Damiano
Aug 19, 2007·Blood·Alexander ZarbockKlaus Ley
Oct 29, 2011·Blood·Debanjan SarkarJeffrey M Karp
Oct 3, 2012·PloS One·Christian PoelmaJerry Westerweel
Nov 2, 2012·Biomechanics and Modeling in Mechanobiology·Joseph M SherwoodStavroula Balabani
Jun 7, 2014·Annual Review of Biomedical Engineering·John M TarbellFitz-Roy E Curry
Feb 21, 2016·Annals of Biomedical Engineering·Aristotle G Koutsiaris
Nov 13, 2012·Molecular Immunology·Prithu SunddKlaus Ley
Jan 26, 2010·Journal of Pharmacological and Toxicological Methods·Ellen L Hughes, Felicity N E Gavins
Apr 5, 2012·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Sven HirschBruno Weber
Jul 22, 2015·Annual Review of Biomedical Engineering·Majid Ebrahimi WarkianiJongyoon Han
Mar 3, 2007·Progress in Cardiovascular Diseases·Demosthenes KatritsisVasilios Marmarelis
Jan 2, 2007·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Renate KoppThorsten Schwerte
May 10, 2006·British Journal of Haematology·D J Bowen, P W Collins
Jul 1, 2008·British Journal of Pharmacology·A ZarbockK Ley
Feb 13, 2013·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Bingmei M Fu, John M Tarbell
Apr 28, 2011·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·C Makena HightowerMarcos Intaglietta
Apr 8, 2014·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Krishna SriramDaniel M Tartakovsky
Sep 28, 2015·Clinical Hemorheology and Microcirculation·Amin ShariatkhahMohammad Reza Heyrani Nobari
May 20, 2009·Biophysical Journal·John E Pickard, Klaus Ley
Aug 5, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Joshua J RychakAlexander L Klibanov
Feb 11, 2014·Biophysical Journal·Jonathan B Freund, Julien Vermot
Jul 24, 2012·Microvascular Research·Hojin HaSang Joon Lee
Feb 23, 2013·Microvascular Research·Michele D SaveryEdward R Damiano

❮ Previous
Next ❯

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.