Microwave-assisted Synthesis and antifungal activity of coumarin[8,7-e][1,3]oxazine derivatives

Molecular Diversity
Ming-Zhi ZhangWei-Hua Zhang

Abstract

The synthesis of novel coumarin[8,7-e][1,3]oxazine derivatives through a microwave-assisted three-component one-pot Mannich reaction is described in this study. All the target compounds were evaluated in vitro for their antifungal activity against Botrytis cinerea, Colletotrichum capsici, Alternaria solani, Gibberella zeae, Rhizoctonia solani, and Alternaria mali. The preliminary bioassays showed that 5e, 5m, and 5s exhibited good antifungal activity and the most active compound was 5m with an [Formula: see text] value as low as 2.1 nM against Botrytis cinerea.

References

Dec 23, 2004·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Jesús M CesarMaría V Herraez
May 25, 2005·Archives of Internal Medicine·Anne M HolbrookPhilip S Wells
Sep 30, 2005·Journal of Medicinal Chemistry·Christos A Kontogiorgis, Dimitra J Hadjipavlou-Litina
Feb 14, 2006·Current Medicinal Chemistry·Massimo CuriniGiovanni Giannone
Feb 2, 2010·European Journal of Medicinal Chemistry·Bijoy P MathewMahendra Nath
Feb 20, 2010·Current Medicinal Chemistry·M E RiveiroC Davio
Feb 10, 2011·Pest Management Science·Ai-Ying GuanZheng-Ming Li
Mar 24, 2011·Journal of Agricultural and Food Chemistry·Sylvia VoglBrigitte Kopp
May 30, 2014·Chemical Reviews·Aiying GuanMark Dekeyser
Oct 14, 2014·Pesticide Biochemistry and Physiology·Congying XuMingguo Zhou
Dec 18, 2014·Journal of Agricultural and Food Chemistry·Changling LiuYong Xie
Jul 21, 2015·European Journal of Medicinal Chemistry·Anuradha ThakurVikas Jaitak

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Citations

Oct 5, 2019·Chemical Biology & Drug Design·Dhafer S ZinadMohammad Rizki Fadhil Pratama
May 31, 2018·Molecular Diversity·Mykola V ProtopopovSergiy M Yarmoluk
Oct 11, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xiang YuWei-Hua Zhang
Jan 16, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Qing-Qing WangWei-Hua Zhang
Sep 24, 2021·Chemical Biology & Drug Design·Svetlana A PopovaIrina Yu Chukicheva

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An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.