Microwave radiation enhances teratogenic effect of cytosine arabinoside in mice

Biology of the Neonate
J MarcickiewiczS Szmigielski

Abstract

Impregnated Swiss mice were irradiated 2 h daily on days 1-18 of gestation in nonthermal (1 or 10 mW/cm2) or thermogenic (40 mW/cm2) 2,450-MHz microwave (MW) fields. On the 19th day of pregnancy all dams were killed to check the number of resorptions. Living fetuses were isolated, weighed and checked for the presence of macroscopically visible malformations of skeleton and cleft palate (CP) and/or lip (CLP). Some of the pregnant mice in each group were injected intraperitoneally on the 9th day of gestation with 10 mg/kg of cytosine arabinoside (ara-C), a well-known teratogen resulting under the above conditions in the appearance of about 15% (42 of 354) of resorbed implantation points and the development of CP or CLP in about 30% (96 of 312) of fetuses. Exposure to nonthermal MW fields during pregnancy did not lead to resorptions or detectable malformations; however, the body mass of 19-day fetuses was significantly lower than in sham-irradiated controls. MW hyperthermia (40 mW/cm2) applied during pregnancy led to an increased number of resorptions - about 25% (37 of 157) compared to 2% (6 of 306) in controls. Significant enhancement of the teratogenic potency of ara-C was observed after combined exposure to both ara-C and MWs ...Continue Reading

Citations

Jun 24, 1998·Mutation Research·L Verschaeve, A Maes
Jul 25, 2014·Nucleic Acids Research·Meghan LarinJ Peter McPherson
May 20, 2011·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Marvin C Ziskin, Joseph Morrissey
Mar 1, 2014·Toxicological Research·Eui-Ju Hong, Eui-Bae Jeung
Jul 23, 2005·Bioelectromagnetics·Jukka Juutilainen

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