Microwave Radiometry-Derived Thermal Changes of Small Joints as Additional Potential Biomarker in Rheumatoid Arthritis: A Prospective Pilot Study

Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases
George PentazosElias Siores


A prospective pilot study was performed using microwave radiometry (MR), a noninvasive method detecting in-depth tissue temperature, to evaluate whether temperature-of-small-joint-derived scores correlate to parameters commonly used to assess disease activity in rheumatoid arthritis (RA). Ten patients with active, untreated RA underwent clinical and laboratory assessments and joint ultrasound and MR of hand and foot small joints at baseline and at 15, 30, and 90 days after treatment onset. Mixed-model analysis for repeated measures was used to compare patient characteristics in sequential visits. Twenty age- and sex-matched healthy individuals served as control subjects. Using 1248 MR-derived separate recordings from patients' joints, several thermoscores involving different joint combinations were created. When compared with clinical and ultrasound data, the best performing thermoscore involved temperatures of 16 joints (second to fifth metacarpal and proximal interphalangeal joints, bilaterally). This thermoscore correlated to the 28-joint Disease Activity Score-C-reactive protein, tender and swollen joint counts, patient's visual analog scale (all P ≤ 0.02), and the standard 7-joint ultrasound score (P < 0.03) and could also...Continue Reading


Feb 1, 1987·British Journal of Rheumatology·S FraserR D Sturrock
Oct 1, 1983·Annals of the Rheumatic Diseases·R S SalisburyD P Page-Thomas
Jun 19, 2001·Annals of the Rheumatic Diseases·M BackhausUNKNOWN Working Group for Musculoskeletal Ultrasound in the EULAR Standing Committee on International Clinical Studies including The
Apr 28, 2012·Journal of the American College of Cardiology·Konstantinos ToutouzasChristodoulos Stefanadis
Jun 7, 2013·PloS One·Evangelia ZampeliPetros P Sfikakis
Dec 25, 2015·Best Practice & Research. Clinical Rheumatology·Joshua F BakerPhilip G Conaghan

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