Microwave synthesis, basic spectral and biological evaluation of some copper (II) mesoporphyrinic complexes.

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Rica BoscencuLuis Filipe Vieira Ferreira

Abstract

Cu(II) complexes with asymmetrical and symmetrical porphyrinic ligands were synthesized with superior yields using microwave irradiation. The paper presents the synthesis of 5-(3-hydroxyphenyl)-10,15,20-tris-(4-carboxymethylphenyl)-21,23-Cu(II)-porphine in comparison to its symmetrical complex 5,10,15,20-meso-tetrakis-(4-carboxy-methylphenyl)-21,23-Cu(II) porphine. The two compounds were characterized by FT-IR, UV-Vis and EPR spectroscopy, which fully confirmed the structures. The spectral molecular absorption properties of the porphyrinic complexes were studied in organic solvents (methanol, ethanol, iso-propanol, dimethyl sulfoxide, dimethylformamide and methylene chloride), and the influence of the solvent polarity on the absorbance maxima is described. In order to establish their future potential in biomedical applications preliminary toxicological studies consisting of viability and proliferation of standard tumor cell lines (MCF7 and B16) testing was performed. The obtained results indicate a low toxicity for both compounds and further recommends them for testing in light activation protocols.

References

May 31, 1991·Biochimica Et Biophysica Acta·F RicchelliM Tronchin
Nov 25, 1983·Journal of Immunological Methods·C Korzeniewski, D M Callewaert
Jun 1, 1994·Lupus·W L Morison
Sep 1, 1996·Photochemistry and Photobiology·R W Boyle, D Dolphin
Feb 7, 2003·Nature·David Adam
May 15, 2003·Chemical Reviews·Claude Schweitzer, Reinhard Schmidt
Jan 21, 2004·Journal of Photochemistry and Photobiology. B, Biology·Emma S Nyman, Paavo H Hynninen
Jun 16, 2004·International Journal of Pharmaceutics·F PostigoM L Sagristá
Jul 23, 2004·Journal of Medicinal Chemistry·Michael R DettyStephen J Wagner
Sep 1, 2004·Bioorganic & Medicinal Chemistry·Stefano BanfiElena Monti
Apr 19, 2007·Current Medicinal Chemistry·J C StockertS Nonell
Oct 22, 2008·Advanced Drug Delivery Reviews·Dev Kumar ChatterjeeYong Zhang
Oct 31, 2008·Talanta·M BiesagaM Trojanowicz

❮ Previous
Next ❯

Citations

Oct 22, 2011·International Journal of Molecular Sciences·Rica BoscencuRadu Socoteanu
Sep 4, 2012·International Journal of Molecular Sciences·Rica BoscencuLuís Filipe Vieira Ferreira
Sep 8, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Radu SocoteanuAnabela Sousa Oliveira
May 19, 2012·Photodiagnosis and Photodynamic Therapy·Mathias O Senge
Oct 27, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Rica BoscencuLuís Filipe Vieira Ferreira
May 12, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Rica Boscencu
Nov 20, 2018·Journal of Cellular and Molecular Medicine·Carolina ConstantinMonica Neagu

❮ Previous
Next ❯

Methods Mentioned

BETA
Assay

Software Mentioned

PHOTOFRIN

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.