MICs of ciprofloxacin and trimethoprim for Escherichia coli: influence of pH, inoculum size and various body fluids

J AagaardP O Madsen


The influence of pH, inoculum size, human urine and prostatic extract on the MICs of ciprofloxacin and trimethoprim for Escherichia coli was investigated. There was no influence by the bacterial inoculum size within wide ranges on either drug. An increase in pH had a variable influence on the MICs of trimethoprim for E. coli but lowered those of ciprofloxacin considerably. Human prostatic extract increased the trimethoprim MIC for E. coli but lowered those of ciprofloxacin as compared to Mueller Hinton broth. Human urine increased the MICs of both drugs for E. coli.


Aug 13, 2013·The Cochrane Database of Systematic Reviews·Gianpaolo PerlettiVittorio Magri
Jul 14, 2018·PloS One·Haitham AlRabiahRoyston Goodacre
May 4, 2016·Antimicrobial Agents and Chemotherapy·Guillermo Martín-GutiérrezJesús Blázquez
Aug 9, 2017·Microbial Genomics·Robert J Goldstone, David G E Smith

Related Concepts

Human urine
Chronic Disease
Escherichia Coli Infections
Chronic Prostatitis With Chronic Pelvic Pain Syndrome
Body Fluids

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