Mid-Gestational Fetal Placental Blood Flow is Diminished in the Fetus with Congenital Heart Disease

Prenatal Diagnosis
Deborah Y HoJ Rychik

Abstract

Data suggest fetuses with congenital heart disease (CHD) have placental abnormalities. Their abnormal placental vasculature may affect fetal placental blood flow, which has not previously been explored. We performed a retrospective cross-sectional study comparing umbilical venous volume flow (UVVF) of single ventricle, D-transposition of the great arteries, and tetralogy of Fallot fetuses with fetuses without CHD. UVVF and combined cardiac output (CCO) were calculated from fetal echocardiography and compared using t-tests, Chi-square and Fisher's exact tests. Mean gestational age and fetal weight were greater in CHD fetuses (26.5 weeks, 1119.4g; n=81, p<0.001) compared to controls (23.1 weeks, 675g; n=170, p<0.001). UVVF/fetal weight was nevertheless decreased among cases (99.8 versus 115.3 mL/min/kg, p<0.001). Subgroup analysis of 20- to 25-week fetuses demonstrated no significant differences in case and control baseline characteristics. In CHD fetuses (n=31) compared to controls (n=144), absolute UVVF (50.8 versus 62.1 mL/min, p=0.006), and UVVF/fetal weight (98.8 versus 118.5 mL/min/kg, p<0.001) were decreased. Findings were similar in single ventricle (n=24) and hypoplastic left heart syndrome (n=14). Mid-gestational placen...Continue Reading

References

Apr 16, 2002·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·S BoitoJ W Wladimiroff
Feb 11, 2004·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·S M E BoitoJ W Wladimiroff
Jul 12, 2008·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·F FiguerasE Gratacós
Mar 5, 2009·The Journal of Thoracic and Cardiovascular Surgery·Daniel J LichtArastoo Vossough
Mar 28, 2009·The Annals of Thoracic Surgery·Anita SzwastJack Rychik
Jun 30, 2010·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·K FloG Acharya
Mar 24, 2011·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Yao-lung ChangPo-jen Cheng
Mar 13, 2012·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·A SzwastJ Rychik
Aug 3, 2012·Journal of Clinical Ultrasound : JCU·Afrooz Najafzadeh, Jan E Dickinson
Dec 1, 2012·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Stephen Z PinterJ Brian Fowlkes
Jun 12, 2013·Seminars in Fetal & Neonatal Medicine·James Huhta, Kersti K Linask
Aug 7, 2013·Placenta·D J P Barker, K L Thornburg
Oct 26, 2013·European Heart Journal·Elisa LlurbaLluís Cabero
Oct 27, 2015·JAMA : the Journal of the American Medical Association·Nathalie AugerLaura Arbour
May 1, 2016·Acta Obstetricia Et Gynecologica Scandinavica·Ganesh AcharyaAnthony Odibo
Feb 16, 2018·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·James William GaynorMark P Johnson
May 29, 2018·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·M J MebiusC M Bilardo
Jul 13, 2018·Obstetric Medicine·Lisa Story, Catherine Nelson-Piercy

❮ Previous
Next ❯

Related Concepts

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

Related Papers

Journal of Perinatal Medicine
Maria Angelica ZoppiGiovanni Monni
Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology
L SunM Seed
American Journal of Obstetrics and Gynecology
Keiko UedaIsao Shiraishi
© 2021 Meta ULC. All rights reserved