Mid-gestational sevoflurane exposure inhibits fetal neural stem cell proliferation and impairs postnatal learning and memory function in a dose-dependent manner

Developmental Biology
Yuan WangPing Zhao

Abstract

Advancements in fetal intervention procedures have led to increases in the number of pregnant women undergoing general anesthesia during the second trimester-a period characterized by extensive proliferation of fetal neural stem cells (NSCs). However, few studies have investigated the effects of mid-gestational sevoflurane exposure on fetal NSC proliferation or postnatal learning and memory function. In the present study, pregnant rats were randomly assigned to a control group (C group), a low sevoflurane concentration group (2%; L group), a high sevoflurane concentration group (3.5%; H group), a high sevoflurane concentration plus lithium chloride group (H + Li group), and a lithium chloride group (Li group) at gestational day 14. Rats received different concentrations of sevoflurane anesthesia for 2 h. The offspring rats were weaned at 28 days for behavioral testing (i.e., Morris Water Maze [MWM]), and fetal brains or postnatal hippocampal tissues were harvested for immunofluorescence staining, real-time PCR, and Western blotting analyses in order to determine the effect of sevoflurane exposure on NSC proliferation and the Wnt/β-catenin signaling pathway. Our results indicated that maternal exposure to 3.5% sevoflurane (H gro...Continue Reading

Citations

Jul 10, 2018·Current Opinion in Anaesthesiology·Ritesh Lamsal, Girija P Rath
Feb 20, 2021·Cellular and Molecular Neurobiology·Xingyue LiPing Zhao
Feb 19, 2021·Frontiers in Pharmacology·Xingyue LiPing Zhao
May 19, 2021·Neurochemical Research·Shaowei YinYuan Wang
Oct 15, 2018·Fetal Diagnosis and Therapy·Olutoyin A OlutoyeOluyinka O Olutoye

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