PMID: 2504079Aug 1, 1989Paper

Midazolam-alfentanil synergism for anesthetic induction in patients

Anesthesia and Analgesia
H R VinikI Kissin

Abstract

The effect of midazolam on the induction dose-response curve for alfentanil was studied in nonpremedicated ASA physical status I or II patients. The response to the verbal command was used as an end point of anesthesia. Dose-response curves for midazolam, alfentanil, and their combination were determined with a probit procedure, and compared with algebraic (fractional) analysis of drug interaction. Interaction between midazolam and alfentanil was found to be synergistic (supraadditive). The results suggest that the use of this combination is advantageous not only because it helps to achieve different anesthetic goals with specific drugs (a benzodiazepine for unconsciousness and an opioid for blockade of the responses to noxious stimulation), but also because its components are complementary for unconsciousness.

Citations

Nov 1, 1995·Journal of Clinical Anesthesia·B K Philip
Oct 1, 1996·Pharmacology, Biochemistry, and Behavior·J P ZacnyJ L Apfelbaum
Sep 1, 1997·Journal of Clinical Anesthesia·I Kissin
Oct 20, 1999·Journal of Clinical Anesthesia·S SchraagM Georgieff
Mar 17, 2006·Critical Care Medicine·Paul S RichmanPeter S Glass
Aug 1, 1996·Anaesthesia·I K DriverR Howard-Griffin
Jan 1, 1994·Acta Anaesthesiologica Scandinavica·L Quist ChristensenJ P Kampmann
Jan 1, 1995·Acta Anaesthesiologica Scandinavica. Supplementum·J G Whitwam
Feb 1, 2003·Vojnosanitetski pregled. Military-medical and pharmaceutical review·Biljana DordevićMilos P Stojiljković
Jan 21, 2006·European Journal of Clinical Pharmacology·Eleonora L SwartRobert M J Strack van Schijndel
Jan 1, 1991·Intensive Care Medicine·H R Vinik, I Kissin
Sep 11, 1991·Journal of Clinical Anesthesia·I KissinE L Bradley
Aug 8, 2008·International Journal of Cardiology·Maurizio RennaMichael Y Henein
Oct 26, 2000·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·M ChristianR Moy
Jul 18, 2008·Anesthesia and Analgesia·Jan F A HendrickxSteven L Shafer
Jan 29, 2020·Journal of Clinical Pharmacology·Lauren L LohmerVirginia D Schmith
May 1, 1997·European Journal of Anaesthesiology. Supplement·P S GlassB Ginsberg

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.