PMID: 2864715Jan 1, 1985

Midazolam cue in rats: generalization tests with anxiolytic and other drugs

Psychopharmacology
H S GarchaI P Stolerman

Abstract

Some characteristics of the discriminative stimulus (cue) effects of midazolam, a short-acting benzodiazepine, have been determined in rats. A standard two-bar operant conditioning procedure with food reinforcers delivered on a tandem schedule was used. The 0.4 mg/kg dose of midazolam used for training was well discriminated, typically yielding at least 95% correct responding. Other benzodiazepines increased the percentage of drug-appropriate responding in a dose-related manner and were generalized at doses which had little effect on the overall rate of responding. Doses of pentobarbitone which greatly reduced the overall rate of responding were also generalized with midazolam. Amphetamine, oxotremorine, picrotoxin, morphine, nicotine, quipazine and Ro 15-1788 were not generalized, even at doses which severely suppressed overall response rates. The midazolam cue possesses a considerable degree of specificity and provides a potentially useful assay for drug action at the benzodiazepine receptor complex.

References

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Citations

Jan 1, 1986·Psychopharmacology·I P StolermanI C Rose
Jan 1, 1989·Psychopharmacology·F Woudenberg, J L Slangen
Jan 1, 1994·Psychopharmacology·D J Sanger, B Zivkovic
Jan 1, 1993·Psychopharmacology·T Wada, N Fukuda
Jan 1, 1993·Psychopharmacology·D M Grech, R L Balster
Aug 21, 2013·Psychopharmacology·L R Gerak, C P France
May 24, 1995·European Journal of Pharmacology·J B AcriJ M Witkin
Aug 1, 1991·Pharmacology, Biochemistry, and Behavior·F Woudenberg, T H Hijzen
Jan 1, 1986·Neuroscience and Biobehavioral Reviews·S O Cole
Jan 1, 1990·Pharmacology & Therapeutics·J S Andrews, D N Stephens
Jul 23, 2003·Pharmacology, Biochemistry, and Behavior·N A Ator
Jan 1, 1997·Pharmacology, Biochemistry, and Behavior·J M WitkinJ E Barrett
Jan 27, 1998·Pharmacology, Biochemistry, and Behavior·M D Schechter
Oct 9, 1999·Pharmacology, Biochemistry, and Behavior·N A Ator
Oct 9, 1999·Pharmacology, Biochemistry, and Behavior·B J Smith, W K Bickel
Oct 9, 1999·Pharmacology, Biochemistry, and Behavior·E A MariathasanJ A White
Jun 1, 1997·Journal of Clinical Psychopharmacology·J H Woods, G Winger
Jan 1, 1987·British Journal of Pharmacology·R KumarI P Stolerman

Related Concepts

Metazoa
Benzodiazepines
Benzodiazepinones
Cues
Dose-Response Relationship, Drug
Romazicon
Generalization, Stimulus
Versed
Diabutal
Anti-Anxiety Effect

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