Midbrain binding of [123I]nor-beta-CIT in atypical depression

Progress in Neuro-psychopharmacology & Biological Psychiatry
Soili LehtoJohannes Lehtonen

Abstract

Altered serotonin (SERT) and dopamine transporter (DAT) densities have been recorded in major depression. Atypical depression (ATD) has been suggested to be connected to decreased serotonergic transmission, but no studies have been published on the association between brain serotonin transporter density and ATD. PATIENTS with depression (n=29) were divided into three groups according to DSM-IV criteria: atypically depressed, melancholic patients, and "undifferentiated" patients. Depressive symptoms were evaluated with the 29-item Hamilton Depression Rating Scale (HAM-D-29). Single photon emission computed tomography (SPECT) with [(123)I]nor-beta-CIT was used to evaluate serotonin transporter density (SERT) in the midbrain and dopamine transporter density (DAT) in the striatum of patients and healthy controls (n=18). All subgroups except those with undifferentiated depression had lower SERT densities compared to controls. No significant differences were found in the densities between the subgroups. Atypical scores of HAM-D-29 were associated with SERT densities in the midbrain (beta=-0.40, t=-2.3, p=0.03), even after adjustment for age, gender and HAM-D-21 scores (beta=-0.39, t=-2.32, p=0.03). The association between atypical sc...Continue Reading

References

Oct 1, 1990·Archives of General Psychiatry·F M QuitkinD F Klein
Aug 1, 1988·Archives of General Psychiatry·J B Williams
Jan 1, 1995·The American Journal of Psychiatry·G M AsnisW C Sanderson
Jul 1, 1997·The American Journal of Psychiatry·R D LevitanS H Kennedy
Aug 31, 2002·The American Journal of Psychiatry·Gordon ParkerDusan Hadzi-Pavlovic
Feb 4, 2003·European Archives of Psychiatry and Clinical Neuroscience·Franco Benazzi
Aug 13, 2003·Archives of General Psychiatry·Louis S MatzaJonathan W Stewart
Feb 1, 1960·Journal of Neurology, Neurosurgery, and Psychiatry·M HAMILTON
Apr 20, 2004·Progress in Neuro-psychopharmacology & Biological Psychiatry·Kostas N FountoulakisGeorge Kaprinis
Jul 9, 2004·Archives of General Psychiatry·Gerard SanacoraGraeme F Mason

❮ Previous
Next ❯

Citations

Nov 28, 2008·European Journal of Nuclear Medicine and Molecular Imaging·Swen HesseOsama Sabri
Feb 3, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Henricus G RuhéAart H Schene
Jun 16, 2012·Psychiatry Research·Andrew B NewbergJustine Shults
Mar 12, 2008·Journal of Psychiatric Research·Jeffrey M MillerRamin V Parsey
Sep 22, 2007·Progress in Neuro-psychopharmacology & Biological Psychiatry·Soili M LehtoJohannes Lehtonen
Dec 17, 2014·Journal of Affective Disorders·Zongchang LiXiaogang Chen
Aug 4, 2011·Neuropsychobiology·Gerald PailSiegfried Kasper
Feb 8, 2019·Perspectives in Psychiatric Care·Janiece E DeSocio
Jun 16, 2011·Medicinal Research Reviews·Louise M PatersonGitte M Knudsen
Jun 12, 2013·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Jay D AmsterdamIrene Soeller
Jun 16, 2009·Behavioural Brain Research·Susanne NikolausHans-Wilhelm Müller
Apr 10, 2012·Behavioural Brain Research·Susanne NikolausHans-Wilhelm Müller

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.