Midbrain hypometabolism as early diagnostic sign for progressive supranuclear palsy

Acta Neurologica Scandinavica
M MishinaY Katayama

Abstract

Progressive supranuclear palsy (PSP) is often misdiagnosed in early phase. The purpose of this study is to investigate the feature of [(18)F]fluoro-2-deoxy-d-glucose (FDG) positron emission tomography images for the early diagnosis of PSP. We studied 15 patients with PSP and 16 normal subjects. Using SPM99 and analysis of covariance to eliminate the effect of aging, the differences between PSP and normals were displayed as a statistical map. In the PSP, we also investigated the correlation with duration and with the subscores of Unified Parkinson's Disease Rating Scale. The glucose metabolism of midbrain was significantly lower in PSP than in normals. However, correlation was not found between the metabolism of midbrain and clinical deterioration. The statistical map clearly demonstrated the hypometabolism of midbrain in PSP, which is independent of the clinical deterioration. The hypometabolism of midbrain is one of the most promising sign for early diagnosis of PSP.

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Citations

Apr 2, 2013·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Hai Cun ShiHong Ye Li
Sep 22, 2010·International Journal of Stroke : Official Journal of the International Stroke Society·Chihiro HosodaKikuo Ohno
Jul 16, 2010·Geriatrics & Gerontology International·Kiichi IshiwataJun Toyohara
Feb 5, 2014·Journal of Neurology·Nicholas ZalewskiKeith A Josephs
May 14, 2008·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·Masahiro Mishina
Nov 21, 2013·Parkinsonism & Related Disorders·Hugo BothaKeith A Josephs
May 13, 2014·Journal of the Neurological Sciences·G PetytF Semah
Apr 8, 2004·Radiology·Meenal B PatwardhanOlivier T Rutschmann
May 14, 2017·Movement Disorders : Official Journal of the Movement Disorder Society·Jennifer L WhitwellUNKNOWN Movement Disorder Society-endorsed PSP Study Group
May 21, 2010·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Pascali Durand-MartelNancy Paquet
Aug 25, 2021·Nature Reviews. Neurology·Maria StamelouGünter U Höglinger

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