Middle age increases tissue vulnerability and impairs sensorimotor and cognitive recovery following traumatic brain injury in the rat

Behavioural Brain Research
Michael HoaneStacy L Akstulewicz

Abstract

With increasing age comes an increased risk for sustaining traumatic brain injuries (TBI). However, the effect of age is rarely studied in animal models of TBI. The present study evaluated the effect of increased age on recovery of function following bilateral medial frontal cortex injury. Groups of young (3 months) and middle-aged (14 months) rats received bilateral frontal cortex contusions or sham injuries. The rats were tested on a variety of tests to measure sensorimotor performance (bilateral tactile adhesive removal test), skilled forelimb use (staircase test), and the acquisition of reference and working memory in the Morris water maze. Results indicated that injury produced significant impairments on all behavioral tests compared to sham controls. Middle-aged rats that received cortical contusions were significantly impaired on the bilateral tactile adhesive removal test, acquisition of a reference memory task, and working memory compared to young-injured rats. Histological analysis showed that middle-aged rats developed significantly larger lesion cavities but did not show an increase in the number of glial fibrillary acidic protein (GFAP+) cells compared to young-injured rats. Age alone also significantly impaired fu...Continue Reading

References

Jan 1, 1992·Trends in Neurosciences·R E Coggeshall
Dec 1, 1991·Journal of Neurosurgery·R J HammR L Hayes
Feb 1, 1990·Stroke; a Journal of Cerebral Circulation·F S SilversteinM V Johnston
Oct 1, 1987·Brain Injury : [BI]·J A WilsonJ D Miller
Jul 1, 1986·Age and Ageing·B PentlandJ D Miller
Sep 15, 1999·JAMA : the Journal of the American Medical Association·D Thurman, J Guerrero
Feb 26, 2000·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·T E JagerP E Pepe
Nov 4, 2000·Journal of Biomedical Science·H J TsayH H Ku
Jul 5, 2003·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·I BadanA Popa-Wagner

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Citations

Feb 24, 2010·Journal of Neurotrauma·Lesley K GilmerStephen W Scheff
Jan 19, 2013·Nature Reviews. Neuroscience·Ye XiongMichael Chopp
Nov 11, 2009·Ageing Research Reviews·Aurel Popa-WagnerZaal Kokaia
Nov 13, 2008·Journal of Neuroscience Methods·Aline de Souza PagnussatCarlos Alexandre Netto
Dec 17, 2014·Neuroscience and Biobehavioral Reviews·Corina O BondiAnthony E Kline
Dec 24, 2010·British Journal of Pharmacology·Niklas Marklund, Lars Hillered
Apr 5, 2011·Neurobiology of Aging·Tara L MooreDouglas L Rosene
Nov 19, 2015·Reviews in the Neurosciences·Shammy ChandelBikash Medhi
Nov 19, 2015·Frontiers in Neurology·Ryan C TurnerCharles L Rosen
Nov 15, 2019·Neurorehabilitation and Neural Repair·Aiwane IboayaRandolph J Nudo
Aug 25, 2020·Oxidative Medicine and Cellular Longevity·Patrizia HreliaSilvana Hrelia
Jun 4, 2020·Ageing Research Reviews·Sophie VanhunselLieve Moons

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