Middle age onset short-term intermittent fasting dietary restriction prevents brain function impairments in male Wistar rats

Biogerontology
Rumani SinghGurcharan Kaur

Abstract

Intermittent fasting dietary restriction (IF-DR) is recently reported to be an effective intervention to retard age associated disease load and to promote healthy aging. Since sustaining long term caloric restriction regimen is not practically feasible in humans, so use of alternate approach such as late onset short term IF-DR regimen which is reported to trigger similar biological pathways is gaining scientific interest. The current study was designed to investigate the effect of IF-DR regimen implemented for 12 weeks in middle age rats on their motor coordination skills and protein and DNA damage in different brain regions. Further, the effect of IF-DR regimen was also studied on expression of energy regulators, cell survival pathways and synaptic plasticity marker proteins. Our data demonstrate that there was an improvement in motor coordination and learning response with decline in protein oxidative damage and recovery in expression of energy regulating neuropeptides. We further observed significant downregulation in nuclear factor kappa B (NF-κB) and cytochrome c (Cyt c) levels and moderate upregulation of mortalin and synaptophysin expression. The present data may provide an insight on how a modest level of short term IF-...Continue Reading

References

Jan 1, 1990·Methods in Enzymology·R L LevineE R Stadtman
Mar 17, 2001·Medicine and Science in Sports and Exercise·C K Sen
Nov 9, 2002·Microscopy Research and Technique·Hae Young ChungByung Pal Yu
May 15, 2003·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·R G M MorrisC O'Carroll
Jun 20, 2003·Proceedings of the National Academy of Sciences of the United States of America·Ruolan LiuMichel Baudry
Sep 6, 2003·Experimental Neurology·C L CadacioC L Cadiacio
Nov 19, 2003·Biochemical and Biophysical Research Communications·Isabelle M Mansuy
Oct 19, 2004·Experimental Gerontology·Ji Hyeon LeeHae Young Chung
Nov 16, 2004·Ageing Research Reviews·Faridis Serrano, Eric Klann
Jun 28, 2005·Cancer Letters·Devanand Sarkar, Paul B Fisher
Jun 9, 2006·Molecular and Cellular Endocrinology·R Fernandez-FernandezM Tena-Sempere
Aug 11, 2006·Ageing Research Reviews·Bronwen MartinStuart Maudsley
Oct 5, 2006·Current Alzheimer Research·Isaac G Onyango, Shaharyar M Khan
Dec 26, 2006·Experimental Gerontology·Sunil C KaulRenu Wadhwa
Feb 20, 2007·Cancer Letters·Custer C DeocarisRenu Wadhwa
Apr 27, 2007·Annals of the New York Academy of Sciences·Sataro GotoRamesh Sharma
Dec 7, 2007·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Elena ValassiFrancesco Cavagnini
Mar 18, 2008·Experimental Neurology·Michelle M AdamsJudy K Brunso-Bechtold
Dec 23, 2008·International Journal of Obesity : Journal of the International Association for the Study of Obesity·M B Zimmermann, I Aeberli
Sep 16, 2009·Annals of Nutrition & Metabolism·Edward L MelansonWilliam T Donahoo
Nov 3, 2009·Neurochemistry International·Aleksandra Mladenovic DjordjevicSelma Kanazir
Mar 20, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Gaga KochlamazashviliAlexander Dityatev
Aug 31, 2010·Brain Research·Juan M CastellanoManuel Tena-Sempere
Sep 14, 2011·Nature Reviews. Endocrinology·Victor M Navarro, Manuel Tena-Sempere

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Citations

Nov 5, 2016·Ageing Research Reviews·Mark P MattsonMichelle Harvie
Feb 8, 2018·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Smilja T TodorovicSelma D Kanazir
Oct 1, 2019·Oxidative Medicine and Cellular Longevity·Anna Laura CremoniniFiammetta Monacelli
May 1, 2019·Journal of Lipid and Atherosclerosis·Gwangho Yoon, Juhyun Song
Sep 9, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Vedangana SainiGurcharan Kaur
Nov 6, 2020·Experimental Gerontology·Stephanie M Muscat, Ruth M Barrientos
Jun 9, 2021·Expert Review of Proteomics·Mariona JovéReinald Pamplona

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