Middle cerebral artery occlusion in Wistar and Fischer-344 rats: functional and morphological assessment of the model

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
R C HerzD J de Wildt

Abstract

Cerebral infarction volume after occlusion of a short proximal segment of the middle cerebral artery (MCA) is reported to be different in Wistar compared to Fischer-344 (F344) rats, in both size and variability. Knowledge about the cause of these differences might enable us to explain and perhaps reduce the variation in infarct volume and create a reproducible model of focal cerebral ischemia in the rat. We investigated in Wistar and F344 rats both the effect of occlusion of a long proximal MCA segment on cerebral infarction volume, visualized by magnetic resonance imaging and histology, and the morphology of the major cerebral arteries. Occlusion of a long proximal MCA segment resulted in a striatal and a small cortical infarction in Wistar and a striatal and sizable cortical infarction in F344 rats (as is the case after occlusion of a short proximal MCA segment). In Wistar rats, however, occlusion of a long proximal MCA segment strongly reduced the variability in infarction volume in comparison to occlusion of a small proximal MCA segment. Analysis of the morphology of the major cerebral arteries showed a significantly higher number of proximal side branches of the long proximal MCA segment in Wistar rates than in F344 rats. ...Continue Reading

References

Feb 1, 1978·Experimental Neurology·P Coyle
Dec 1, 1975·Experimental Neurology·P Coyle
Jan 1, 1976·Stroke; a Journal of Cerebral Circulation·Y YamoriM Fukase
Jun 1, 1991·Stroke; a Journal of Cerebral Circulation·R A KnightD Peck
Oct 1, 1990·The Anatomical Record·A Van Der Zwan, B Hillen
Jul 1, 1986·Stroke; a Journal of Cerebral Circulation·S T ChenJ D Balentine
Aug 1, 1988·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·D Duverger, E T MacKenzie
May 1, 1986·Stroke; a Journal of Cerebral Circulation·J B BedersonH Bartkowski
Nov 1, 1982·Stroke; a Journal of Cerebral Circulation·P Coyle
Jan 1, 1981·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·A TamuraG M Teasdale
Dec 1, 1993·Stroke; a Journal of Cerebral Circulation·A van der ZwanM Dujovny
Dec 1, 1993·Stroke; a Journal of Cerebral Circulation·G FoxG Swayne
Nov 1, 1960·The Journal of Physiology·L Symon

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Citations

Jan 25, 2012·European Journal of Nuclear Medicine and Molecular Imaging·Alexandra WinkelerBertrand Tavitian
Jul 26, 2005·Stroke; a Journal of Cerebral Circulation·Juergen BardutzkyMarc Fisher
Jun 1, 2011·Cellular and Molecular Life Sciences : CMLS·Anu Lipsanen, Jukka Jolkkonen
Jan 5, 2010·Experimental Neurology·Mihai MoldovanAurel Popa-Wagner
Mar 15, 2006·Journal of Neuroscience Methods·Michael S DittmarFelix Schlachetzki
Sep 27, 2007·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·B A CoertF B Meyer
Mar 4, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·T PfefferkornG F Hamann
Dec 23, 2003·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Yubo RenThaddeus S Nowak
Jul 1, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Susanne WegenerMathias Hoehn
Jul 31, 2001·NMR in Biomedicine·M BesselmannM Hoehn
Jul 8, 2000·Neuropathology and Applied Neurobiology·B S AspeyM J Harrison
Jan 15, 1999·Neuropathology and Applied Neurobiology·B S AspeyM J Harrison
Oct 25, 2003·Stroke; a Journal of Cerebral Circulation·Mariana BroziciBerend Hillen

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Methods Mentioned

BETA
PCA

Software Mentioned

IBAS
NMRi

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