Middle ear effusion induced by various inflammatory mediators and neuropeptides. An experimental study in the rat.

Acta Oto-laryngologica
P GoldieL A Idahl

Abstract

Vascular leakage in the middle ear cavity was studied after i.v. administration of various substances in rats and determined by the Evans blue technique. Bradykinin, histamine, serotonin, acetylcholine, substance P (SP) and vasoactive intestinal polypeptide (VIP) resulted in extravasation of Evans blue. In the case of bradykinin and histamine, the leakage was dose dependent. Calcitonin gene-related peptide (CGRP) did not affect vessel permeability. In other experiments the effect of histamine antagonists was tested on production of middle ear effusion, caused by blowing air at 14 degrees C into the external auditory canal (EAC). The increase in vessel permeability in this otitis media model was inhibited by the H2-receptor antagonist cimetidine, at doses 0.1 and 1.0 mg/ml. Diphenhydramine, an H1-receptor antagonist, arrested only partly middle ear fluid accumulation. Our study demonstrated that various inflammatory mediators and neuropeptides are capable of inducing vascular leakage in the middle ear cavity. It was also concluded that H2-receptors are involved in the regulation of middle ear vascular permeability.

References

Mar 1, 1978·Otolaryngology·J M BernsteinN Back
Jul 1, 1977·The Annals of Thoracic Surgery·C W SmithD J Delany
Apr 1, 1987·British Medical Bulletin·J C Foreman
Apr 1, 1987·The Journal of Physiology·L A LaitinenJ G Widdicombe
Jul 1, 1988·Acta Oto-laryngologica·P Goldie, S Hellström
Jan 1, 1984·Journal of Cardiovascular Pharmacology·I Marshall
Feb 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·J M LundbergK Folkers

❮ Previous
Next ❯

Citations

Jun 1, 2005·International Journal of Pediatric Otorhinolaryngology·Anton ChenJ Douglas Swarts
May 17, 2000·Burns : Journal of the International Society for Burn Injuries·L LindblomP Löwhagen Hendén
Jun 14, 2012·Acta Oto-laryngologica·Hulya EyigorNuray Erin
Dec 1, 1993·The Annals of Otology, Rhinology, and Laryngology·P GoldieS Hellström
Oct 20, 2001·The Annals of Otology, Rhinology, and Laryngology·E J JeonT T Jung
Jul 2, 2003·The Annals of Otology, Rhinology, and Laryngology·Per Olof ErikssonSten Hellström
Oct 1, 1990·The Annals of Otology, Rhinology, and Laryngology·P Goldie, S Hellström
May 13, 2009·Clinical and Experimental Otorhinolaryngology·Steven K JuhnTina Huang
May 14, 2005·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Sema BasakMurat Sarierler
Mar 1, 1992·The Journal of Urology·M HohenfellnerE A Tanagho
Jul 9, 1999·The Journal of Laryngology and Otology·S BaşakK K Metin
Dec 11, 2019·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Michael H Froehlich, Paul R Lambert

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.