Middle East respiratory syndrome coronavirus: transmission, virology and therapeutic targeting to aid in outbreak control.

Experimental & Molecular Medicine
Prasannavenkatesh DuraiSangdun Choi

Abstract

Middle East respiratory syndrome coronavirus (MERS-CoV) causes high fever, cough, acute respiratory tract infection and multiorgan dysfunction that may eventually lead to the death of the infected individuals. MERS-CoV is thought to be transmitted to humans through dromedary camels. The occurrence of the virus was first reported in the Middle East and it subsequently spread to several parts of the world. Since 2012, about 1368 infections, including ~487 deaths, have been reported worldwide. Notably, the recent human-to-human 'superspreading' of MERS-CoV in hospitals in South Korea has raised a major global health concern. The fatality rate in MERS-CoV infection is four times higher compared with that of the closely related severe acute respiratory syndrome coronavirus infection. Currently, no drug has been clinically approved to control MERS-CoV infection. In this study, we highlight the potential drug targets that can be used to develop anti-MERS-CoV therapeutics.

References

Apr 28, 2001·Cytokine & Growth Factor Reviews·D E Levy, A García-Sastre
Aug 24, 2005·Proceedings of the National Academy of Sciences of the United States of America·Shutoku MatsuyamaFumihiro Taguchi
Sep 6, 2005·Advances in Virus Research·Cornelis A M de Haan, Peter J M Rottier
Dec 13, 2005·Microbiology and Molecular Biology Reviews : MMBR·Susan R Weiss, Sonia Navas-Martin
Dec 27, 2005·The Pediatric Infectious Disease Journal·Jeffrey S Kahn, Kenneth McIntosh
Aug 25, 2006·Journal of Virology·Stanley G SawickiStuart G Siddell
Aug 26, 2006·Cytokine & Growth Factor Reviews·Alfons Billiau
Mar 24, 2007·Biochimie·Takashi FujitaMitsutoshi Yoneyama
Aug 2, 2007·Immunology and Cell Biology·Alex J V Thompson, Stephen A Locarnini
Oct 16, 2007·Experimental & Molecular Medicine·Jayalakshmi KrishnanSangdun Choi
Feb 10, 2009·Nature Reviews. Microbiology·Lanying DuShibo Jiang
May 12, 2009·Nature Reviews. Microbiology·Stanley Perlman, Jason Netland
Sep 3, 2011·Immunological Reviews·Hiroki KatoTakashi Fujita
Oct 19, 2012·The New England Journal of Medicine·Ali M ZakiRon A M Fouchier
Feb 23, 2013·Experimental & Molecular Medicine·Muhammad Ayaz AnwarSangdun Choi
Apr 27, 2013·The Journal of General Virology·Adriaan H de WildeBernadette G van den Hoogen
Jul 26, 2013·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Jasper Fuk-Woo ChanPatrick Chiu-Yat Woo
Aug 14, 2013·Cell Research·Berend Jan BoschBart L Haagmans
Sep 13, 2013·Journal of Virology·Daniela NiemeyerMarcel A Müller
Oct 3, 2013·American Journal of Respiratory and Critical Care Medicine·Andreas C HockeThorsten Wolff
Oct 8, 2013·The Journal of Infection·Jasper F W ChanKwok-Yung Yuen
Nov 13, 2013·Nature Reviews. Microbiology·Rachel L GrahamRalph S Baric
Jan 25, 2014·Emerging Infectious Diseases·Isabella EckerleChristian Drosten
Mar 4, 2014·Expert Review of Clinical Pharmacology·Jaffar A Al-Tawfiq, Ziad A Memish

❮ Previous
Next ❯

Citations

Jan 5, 2016·Epidemiology and Health·Yong-Shik ParkMoran Ki
Dec 13, 2016·Expert Opinion on Therapeutic Targets·Lanying DuShibo Jiang
Jan 24, 2017·Journal of Enzyme Inhibition and Medicinal Chemistry·Ji-Young ParkWoo Song Lee
Jun 20, 2017·Journal of Infection and Public Health·Ali A RabaanJaffar A Al-Tawfiq
Sep 1, 2017·Journal of Medical Microbiology·Ali A RabaanHatem M Alhani
Jul 10, 2018·CA: a Cancer Journal for Clinicians·Ella J Ariza-Heredia, Roy F Chemaly
Aug 28, 2018·Journal of Cellular Physiology·Somayeh ShokriFatemeh Farshadpour
Sep 7, 2017·Journal of Korean Medical Science·Soo Young JeongJong Hwa Kim
Nov 29, 2017·Healthcare Informatics Research·Dong-Woo Seo, Soo-Yong Shin
May 30, 2019·EcoHealth·Sophie ZhuSharon L Deem
Feb 28, 2016·Virologica Sinica·Lanlan LiuJiahai Lu
May 21, 2020·The Pediatric Infectious Disease Journal·Li-Jing XiongXiao-Li Xie
Jan 7, 2017·BMC Infectious Diseases·Fadilah Sfouq AleanizyRania Ali El Hadi Mohamed
May 14, 2017·Frontiers of Medicine·Ali A RabaanJaffar A Al-Tawfiq
Aug 23, 2017·Expert Review of Respiratory Medicine·Ali A Rabaan
Mar 8, 2017·Disaster and Military Medicine·Michael ShapiroItay Fogel
Mar 30, 2017·Proceedings of the National Academy of Sciences of the United States of America·Kun LiPaul B McCray
Mar 24, 2020·Future Virology·Hani ChoudhryMohammad Sarwar Jamal
Jan 27, 2021·Journal of Virological Methods·Riya BhattacharyaAnuradha Sourirajan
Jan 29, 2021·Journal of Medical Virology·Shaghayegh Khanmohammadi, Nima Rezaei
Apr 3, 2021·Microbiology Insights·Nihala Naseefa Chathappady HouseHoney Sebastian
Aug 26, 2021·NPJ Vaccines·Mona O MohsenMartin F Bachmann
Oct 27, 2021·Journal of Biomolecular Structure & Dynamics·B S SanjeevArumugam Madhumalar
Aug 25, 2020·Acta Pharmaceutica Sinica. B·Yanfang XianHongxi Xu

❮ Previous
Next ❯

Methods Mentioned

BETA
electron tomography
ubiquitination
deubiquitination
transfection
biosensor

Related Concepts

Related Feeds

Allergy & Infectious Diseases (ASM)

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Allergy & Infectious Diseases

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.

Related Papers

Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin
A J Kucharski, C L Althaus
Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin
N Nowotny, J Kolodziejek
Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin
E KaragozV Turhan
© 2021 Meta ULC. All rights reserved