PMID: 6404945May 1, 1983Paper

Middle Eastern intestinal lymphoma: a morphological and immunohistochemical study

Journal of Clinical Pathology
P IsaacsonD Y Mason

Abstract

A total of 31 cases of Middle Eastern gastrointestinal lymphoma (from Mosul, Iraq) has been analysed by conventional histology, and also by immunoperoxidase staining of trypsinised paraffin sections with anti-Ig and anti-J chain antisera. Histologically these neoplasms fell into three categories: undifferentiated lymphoma of Burkitt type (8 cases); follicle centre cell (FCC) lymphoma, resembling European lymphomas of FCC origin (15 cases); and Mediterranean lymphoma (MTL) (3 cases). Immunohistological staining of the FCC neoplasms showed that these tumours resembled their European counterpart in that cytoplasmic Ig and J chain could be demonstrated in a proportion of cases. However there was a striking difference in that alpha chain alone, light chain alone, or J chain alone were detected in several cases (in contrast to the predominance of mu plus kappa or lambda light chains found in European cases). Furthermore, prominent intracellular inclusions of alpha chains were found in two cases. Staining of the MTL cases revealed that the characteristic mucosal plasma cell infiltrate was positive for alpha chain (weakly) and J chain (strongly) but that the invasive cells which morphologically resembled FCCs were negative for both con...Continue Reading

References

Aug 1, 1979·Journal of Clinical Pathology·P Isaacson
Oct 1, 1979·The American Journal of Surgical Pathology·P Isaacson
Jan 15, 1979·International Journal of Cancer. Journal International Du Cancer·A Al-AttarT Al-Saleem
May 1, 1979·The Histochemical Journal·B L MephamB S Mitchell
Jun 1, 1978·The American Journal of Surgical Pathology·P HaghighiN Mostafavi
Jul 3, 1980·The New England Journal of Medicine·J C RambaudF Danon
Aug 1, 1980·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·P IsaacsonS V Payne

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Citations

Jan 1, 1985·Virchows Archiv. A, Pathological Anatomy and Histopathology·G Kelényi
Jul 1, 1987·Baillière's Clinical Gastroenterology·J Spencer, P G Isaacson
Jun 1, 1985·Journal of Clinical Pathology·P G Isaacson, S K Price
Feb 9, 2012·Neurosurgery·Sebastian A AhmadiSven O Eicker
Jun 1, 1991·Scottish Medical Journal·C KyriacouR E Mass

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