Middle-sized molecule fractions isolated from uremic ultrafiltrate and normal urine inhibit ingestive behavior in the rat.

Journal of the American Society of Nephrology : JASN
B AnderstamJ C Bergström

Abstract

Uremic patients with suppressed food intake may regain appetite soon after starting dialysis, presumably because of the removal of one or more toxic factors that suppress appetite. To investigate this matter, this study used a new experimental model in free-moving, unstressed male Wistar rats (300 to 350 g) with feeding catheters channeled from the top of the skull to the oral cavity. When the rats recovered from surgery, they were tested under standardized conditions by being given an intraoral infusion (1 mL/min) of a 1 M sucrose solution or a 97 g/L protein solution or a mixed solution of carbohydrate, protein, and fat (Fortimel (Nutricia Nordica AB, Stockholm, Sweden)) while the time (volume) of ingestion was recorded. Solutions to be tested for their ability to inhibit ingestion were injected intraperitoneally (lp) and the intraoral infusion was started 20 min later. Plasma ultrafiltrate was collected from end-stage renal failure patients by isolated ultrafiltration at the beginning of their first hemodialysis and pooled. Ultrafiltrate was also obtained by filtering pooled plasma from healthy volunteers in vitro, using the same type of dialyzer and cellulose acetate membranes as those used in the uremic patients. Morning u...Continue Reading

Citations

Nov 10, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·F LocatelliD Spotti
Jun 28, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·M J WrightJ H Turney
Nov 26, 2003·Journal of the American Society of Nephrology : JASN·Alfred K CheungGarabed Eknoyan
Aug 14, 1999·Journal of the American Society of Nephrology : JASN·R Vanholder, R De Smet
Nov 30, 1999·Journal of the American Society of Nephrology : JASN·C L MeirelesW E Mitch
Aug 11, 2000·Kidney International. Supplement·A DhondtN Lameire
Aug 11, 2000·Kidney International. Supplement·M Laville, D Fouque
Apr 24, 1999·Journal of the American Society of Nephrology : JASN·A H MamounJ Bergström
May 26, 2001·Annual Review of Nutrition·R Mehrotra, J D Kopple
Jun 28, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Lara B PupimT Alp Ikizler
Aug 8, 2002·Kidney International·Kayser CaglarT Alp Ikizler
May 20, 2003·Seminars in Dialysis·James T McCarthyRicardo Correa-Rotter
Jun 6, 2003·Kidney International·Francisco MaduellJ Antonio Ferrero
Oct 9, 2003·Kidney International. Supplement·George A Kaysen
Apr 16, 2003·The American Journal of the Medical Sciences·Stephen A MorseEfrain Reisin
Dec 13, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Mark WrightJohn Turney
Apr 20, 2004·Current Opinion in Clinical Nutrition and Metabolic Care·Lara B PupimT Alp Ikizler
Mar 27, 2004·Seminars in Dialysis·Bertrand L Jaber, Deborah L Zimmerman
Apr 1, 2004·Hemodialysis International·Deborah L Zimmerman
Jul 15, 2004·Seminars in Dialysis·Ehab SaadDominic S C Raj
Jan 22, 2005·Seminars in Dialysis·Tejinder S Ahuja, William E Mitch
Jan 1, 2003·Hemodialysis International·Raymond C VanholderRita V De Smet
Sep 30, 2005·Hemodialysis International·Francisco Maduell
Mar 24, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Charles H BeerenhoutJeroen P Kooman
Feb 5, 2002·Expert Opinion on Pharmacotherapy·A AguileraV Alvarez
Sep 1, 2005·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Maurizio BossolaGiovanna Luciani
Jan 21, 2006·Seminars in Dialysis·Libbie P Briley, Lynda A Szczech
Jun 16, 2006·Kidney International·M BossolaG Luciani
Mar 15, 2006·Seminars in Nephrology·Lara B PupimT Alp Ikizler
Aug 31, 2006·Nature Clinical Practice. Nephrology·Robert H MakDaniel L Marks
Dec 20, 2007·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Juan Jesús CarreroBengt Lindholm
Jan 23, 1999·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·W E Mitch, B J Maroni
Feb 19, 1999·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J K LeypoldtF K Port
Oct 12, 1999·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·D S RajJ Work
Jan 7, 2004·Advances in Renal Replacement Therapy·Rajnish Mehrotra, Joel D Kopple
Apr 15, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·L W Henderson
Jan 6, 2009·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Maurizio BossolaGiovanna Luciani
Jan 5, 2011·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Juan J Carrero

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.