Midkine, a retinoic acid-inducible heparin-binding cytokine, is a novel regulator of intracellular calcium in human neutrophils

Biochemical and Biophysical Research Communications
T TakadaT Muramatsu

Abstract

Midkine (MK), which induces chemotaxis of human neutrophils, was found to trigger mobilization of intracellular calcium of these cells. The maximum response was observed 150 sec after exposure to MK, suggesting a complex mechanism in the process. The calcium mobilization was inhibited by herbimycin A, Bordetella pertussis toxin and wortmannin, suggesting that a tyrosine kinase, a G protein-linked receptor and phosphatidyl inositol 3 kinase are involved in the process.

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Citations

Jul 18, 2002·The Journal of Biological Chemistry·Gerald E StoicaAnton Wellstein
Apr 25, 2000·Biochemical and Biophysical Research Communications·H MuramatsuT Muramatsu

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