Midkine and its clinical significance in endometrial carcinoma

Cancer Science
Kojiro TanabeNobuo Yaegashi

Abstract

Midkine (MK) is a secreted heparin-binding growth factor. Several types of human cancer have increased MK expression with elevated serum levels. The purpose of this study was to determine whether MK was expressed in endometrial carcinoma and to evaluate the clinicopathological significance of serum MK in patients with endometrial carcinoma. Immunohistochemical expression of MK was evaluated in 85 endometrial carcinoma samples and 33 controls. MK expression was significantly higher in the carcinomas than in normal endometrium (P < 0.001). Interestingly, MK expression was highest at the margins of invasion and low in the superficial areas of the tumor samples. Using ELISA, we compared serum MK concentration in 120 endometrial carcinoma patients with the concentration in 46 patients with benign gynecologic tumors. Serum MK value in patients with cancer was significantly higher than that in the patients with benign diseases (P = 0.01). Patients with positive lymph node metastasis or recurrence, or cancer death, had a higher serum MK level (P = 0.008, P = 0.009, respectively). In conclusion, MK immunoreactivity in endometrial carcinoma is significantly higher than in normal endometrium. Additionally, preoperative serum MK levels are...Continue Reading

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Citations

Jul 3, 2009·Inflammatory Bowel Diseases·Malgorzata Krzystek-KorpackaMalgorzata Matusiewicz
May 9, 2012·International Journal of Colorectal Disease·Malgorzata Krzystek-KorpackaAndrzej Gamian
May 1, 2010·Proceedings of the Japan Academy. Series B, Physical and Biological Sciences·Takashi Muramatsu
Dec 6, 2012·Journal of Cancer Research and Clinical Oncology·Mingming LvYayi Hou
Aug 1, 2013·Cytokine·Malgorzata Krzystek-KorpackaAndrzej Gamian
Sep 16, 2011·American Journal of Clinical Pathology·Yi-Ju HungKuo-Jang Kao
Jan 6, 2018·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Rami FaresNazem Shams
Feb 26, 2014·Molecular Cancer Research : MCR·Tamina RawnaqCenap Güngör

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