Midkine counteracts the activin signal in mesoderm induction and promotes neural formation

Journal of Biochemistry
C YokotaK Kadomatsu

Abstract

Midkine (MK) is a heparin-binding growth factor that has been implicated in neural survival and differentiation, fibrinolysis, and carcinogenesis. It is expressed in the nervous system during early Xenopus development. In the present study, we demonstrated that injection of vegetal blastomeres with Xenopus MK at the 8-cell stage results in incomplete invagination. In the case of dorsal vegetal injection, hypertrophic neural tissue is produced. Animal caps isolated from embryos that have been injected with Xenopus MK and cultured with activin do not elongate, and all mesoderm markers examined, including both head and trunk/tail ones, are greatly diminished. In contrast, head-specific neural markers, XANF-1 and Xotx2, are induced, while trunk/tail neural markers, XlHbox6 and F-spondin, are decreased. Moreover, MK showes the same effects in animal caps injected with Xenopus Smad2 mRNA.

Citations

Mar 12, 2004·Cancer Letters·Kenji Kadomatsu, Takashi Muramatsu
Sep 4, 1998·Development, Growth & Differentiation·H TiedemannH Tiedemann
Jun 1, 2000·Development, Growth & Differentiation·N MoriyaM Asashima
Apr 30, 2004·Journal of Neurotrauma·Harutoshi SakakimaShuji Izumo
Apr 30, 2013·Journal of Biochemistry·Kenji KadomatsuShoma Tsubota
Sep 7, 2002·Molecular and Cellular Biology·Yoshihisa ShibataKenji Kadomatsu
Jul 15, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S OhtaT Muramatsu
May 1, 2010·Proceedings of the Japan Academy. Series B, Physical and Biological Sciences·Takashi Muramatsu
Apr 25, 2000·Biochemical and Biophysical Research Communications·A EisakiM Asashima
Apr 25, 2009·Proteomics·Séverine A DegrelleNeil C Talbot
Sep 3, 2013·British Journal of Pharmacology·T Muramatsu
Jan 28, 2014·British Journal of Pharmacology·Yoshihiro YoshidaMasako Ikutomo
Jan 3, 2001·Developmental Biology·C Winkler, R T Moon
Oct 27, 2006·Cell Biochemistry and Function·Natsuyo AkuzawaTakao Shinozawa
Nov 24, 2006·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Hisako MuramatsuTakashi Muramatsu
Apr 19, 2006·Laboratory Investigation; a Journal of Technical Methods and Pathology·Peng ZouTakashi Muramatsu
Nov 17, 2020·Frontiers in Neurology·Emily Ross-MunroDavid W Walker

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