Abstract
The aims of this study were to investigate midkine (MK) expression patterns in salivary gland tumors (SGTs) and to evaluate the correlation between MK expression and the degree of malignancy. We performed immunohistochemistry to examine MK expression in specimens of adenoid cystic carcinoma (ACC), mucoepidermoid carcinoma (MEC), and pleomorphic adenoma (PA). In addition, we performed immunohistochemistry for CD31 and measured microvessel density (MVD), which is an indicator of angiogenesis. Immunohistochemistry showed that MK protein expression was significantly higher in specimens of malignant SGTs (ACC [P<0.01] and MEC [P<0.001]) than in benign SGT (PA) samples. Furthermore, MVD values tended to be higher in cases that exhibited high expression of MK, which indicated a significant correlation between the degree of MK expression and MVD (P<0.001). These results suggest that MK may play important roles in malignant transformation and tumor angiogenesis in SGTs.
References
Jan 3, 1991·The New England Journal of Medicine·N WeidnerJ Folkman
Jun 14, 1991·Biochemical and Biophysical Research Communications·H Muramatsu, T Muramatsu
Jan 1, 1986·Head & Neck Surgery·R H Spiro
Sep 1, 1994·Cancer·R I GarverP G Milner
Mar 16, 1995·Brain Research. Developmental Brain Research·Y YoshidaT Muramatsu
Nov 1, 1993·American Journal of Respiratory Cell and Molecular Biology·R I GarverP G Milner
Oct 15, 1993·Brain Research. Developmental Brain Research·J SatohS U Kim
Aug 1, 1997·Journal of Biochemistry·T TakadaT Muramatsu
Nov 5, 1999·Oncology·N KonishiK Kadomatsu
Mar 25, 2000·Journal of Biochemistry·M QiK Kadomatsu
Sep 7, 2002·Molecular and Cellular Biology·Yoshihisa ShibataKenji Kadomatsu
Mar 6, 2003·Medicina oral : órgano oficial de la Sociedad Española de Medicina Oral y de la Academia Iberoamericana de Patología y Medicina Bucal·J-M Aguirre-Urizar
May 18, 2004·Arthritis and Rheumatism·Kiyoko MaruyamaTakashi Muramatsu
Aug 17, 2004·International Journal of Oral and Maxillofacial Surgery·F A AlvesL P Kowalski
May 18, 2005·Oncogene·Bernard L MirkinAbdelhadi Rebbaa
Aug 2, 2005·International Journal of Oral and Maxillofacial Surgery·F A ItoM A Lopes
Jul 11, 2006·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·A V Jones, C D Franklin
Jul 13, 2006·Cancer·Yoshifumi TakeiTakashi Muramatsu
Nov 18, 2006·International Journal of Oral and Maxillofacial Surgery·M RuanC Zhang
Jun 15, 2007·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·M Krzystek-KorpackaT Banas
Citations
May 10, 2015·Expert Opinion on Therapeutic Targets·Stamatios TheocharisJerzy Klijanienko
Oct 30, 2013·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Tai-Jan ChiuHock-Liew Eng
Jan 23, 2016·Cancer Medicine·Taku YamashitaAkihiro Shiotani
Oct 21, 2014·Proteomics·Nazia SyedAditi Chatterjee
Nov 30, 2013·British Journal of Pharmacology·Kenji KadomatsuPéter Ferdinandy
Jun 26, 2015·Cellular and Molecular Life Sciences : CMLS·Sonia SelbonneVéronique Arocas
Dec 5, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Azadeh Andisheh-TadbirShahab Ahmadi
May 20, 2016·Stem Cells Translational Medicine·Johannes BargehrSanjay Sinha
Nov 9, 2017·International Journal of Molecular Sciences·Hyun-Min KimBong-Wook Park
Jun 19, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Ludwig T WeckbachBarbara Walzog
Jul 1, 2017·Physiology International·E ÖzkökŞ Tamer
Sep 4, 2020·Scientific Reports·Jeffrey WangVincent W Lee
Mar 17, 2017·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Lélia Batista de SouzaLélia Maria Guedes Queiroz
Feb 26, 2014·Molecular Cancer Research : MCR·Tamina RawnaqCenap Güngör
Jun 30, 2021·Scientific Reports·Sonia SelbonneVéronique Arocas