Midkine mRNA is overexpressed in pancreatic cancer.

Digestive Diseases and Sciences
Seiji OhhashiMasao Tanaka

Abstract

Midkine (MK) has been reported to be a possible molecular marker for the diagnosis of pancreatic cancer. We investigated the feasibility of quantitative analysis of MK mRNA by quantitative real-time RT-PCR (qRT-PCR) as a promising tool for the diagnosis of pancreatic cancer. We found that pancreatic cancer tissues expressed significantly higher levels of MK mRNA than intraductal pancreatic mucinous neoplasm (IPMN) and non-neoplastic pancreatic tissues (P < 0.05); in contrast, we did not find any differences in MK mRNA expression between IPMN and non-neoplastic pancreatic tissues. Additionally, we observed that poorly differentiated carcinoma samples expressed higher levels of MK mRNA than well-differentiated carcinoma samples, although a significant difference was not observed. The present data suggests that quantitative analysis of MK mRNA provides an objective and sensitive evaluation and may be a promising modality for the diagnosis of pancreatic cancer and the prediction of its prognosis.

References

Jun 14, 1991·Biochemical and Biophysical Research Communications·H Muramatsu, T Muramatsu
Apr 21, 1995·The Journal of Biological Chemistry·S KojimaT Muramatsu
Feb 6, 1996·Biochemical and Biophysical Research Communications·T KanameK Yamamura
Mar 1, 1997·Breast Cancer Research and Treatment·I MiyashiroT Akiyama
Jun 12, 2003·Archives of Surgery·Chad A WiesenauerJames A Madura
Mar 12, 2004·Cancer Letters·Kenji Kadomatsu, Takashi Muramatsu
Mar 31, 2004·Lancet·Donghui LiJames L Abbruzzese
Jan 15, 2005·Cancer Science·Yuki ObataUNKNOWN Tokyo Research Group on Prevention of Gastric Cancer
Jul 30, 2005·International Journal of Cancer. Journal International Du Cancer·Kenoki OhuchidaMasao Tanaka
Nov 10, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kenoki OhuchidaMasao Tanaka
Dec 6, 2005·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·M RodallecY Menu
Nov 18, 2006·International Journal of Oral and Maxillofacial Surgery·M RuanC Zhang
Jul 12, 2007·British Journal of Cancer·S MaedaS Takao

❮ Previous
Next ❯

Citations

Jun 26, 2012·Pathology International·Kazuma Sakamoto, Kenji Kadomatsu
Mar 25, 2014·World Journal of Gastroenterology : WJG·Jun YaoShe-Gan Gao
Jan 1, 2010·Cancers·Hirofumi Jono, Yukio Ando
Jul 3, 2009·Inflammatory Bowel Diseases·Malgorzata Krzystek-KorpackaMalgorzata Matusiewicz
Dec 6, 2019·Oncogene·Panagiota S FilippouAnastasia Constantinidou

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Ductal

Ductal carcinoma is a malignant neoplasm involving the ductal systems of any of a number of organs, such as the mammary glands, pancreas, prostate or lacrimal gland. Discover the latest research on ductal carcinoma here.