Midlife and Late-Life Vascular Risk Factors and White Matter Microstructural Integrity: The Atherosclerosis Risk in Communities Neurocognitive Study

Journal of the American Heart Association
Melinda C PowerThomas H Mosley

Abstract

Diffusion tensor imaging measures of white matter (WM) microstructural integrity appear to provide earlier indication of WM injury than WM hyperintensities; however, risk factors for poor WM microstructural integrity have not been established. Our study quantifies the association between vascular risk factors in midlife and late life with measures of late-life WM microstructural integrity. We used data from 1851 participants in ARIC (Atherosclerosis Risk in Communities Study) who completed 3-T magnetic resonance imaging, including diffusion tensor imaging, as part of the ARIC Neurocognitive Study (ARIC-NCS). We quantified the association among lipids, glucose, and blood pressure from the baseline ARIC visit (1987-1989, ages 44-65, midlife) and visit 5 of ARIC (2011-2013, ages 67-90, late life, concurrent with ARIC-NCS) with regional and overall WM mean diffusivity and fractional anisotropy obtained at ARIC visit 5 for ARIC participants. We also considered whether these associations were independent of or modified by WM hyperintensity volumes. We found that elevated blood pressure in midlife and late life and elevated glucose in midlife, but not late life, were associated with worse late-life WM microstructural integrity. These ...Continue Reading

References

Feb 1, 1984·Journal of Clinical Chemistry and Clinical Biochemistry. Zeitschrift Für Klinische Chemie Und Klinische Biochemie·U NägeleW Gruber
Jul 22, 2005·Lancet Neurology·Chengxuan QiuLaura Fratiglioni
Sep 28, 2005·Neurology·David S KnopmanUNKNOWN Atherosclerosis Risk in Communities (ARIC) Study
Dec 20, 2005·Lancet Neurology·Geert Jan BiesselsPhilip Scheltens
Jan 6, 2006·Annals of the New York Academy of Sciences·D H SalatA M Dale
Jun 30, 2007·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Andrew L AlexanderAaron S Field
Jan 29, 2008·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Arani NitkunanHugh S Markus
Jul 19, 2008·Stroke; a Journal of Cerebral Circulation·Ewoud J van DijkMonique M B Breteler
Sep 19, 2008·Acta Neurologica Scandinavica·K HannesdottirH S Markus
May 6, 2009·Archives of General Psychiatry·Meike W VernooijMonique M B Breteler
Oct 24, 2009·Stroke; a Journal of Cerebral Circulation·Alasdair M J MaclullichJoanna M Wardlaw
Nov 21, 2009·Stroke; a Journal of Cerebral Circulation·Rebecca F GottesmanThomas H Mosley
Jan 13, 2011·Statistics in Medicine·Ian R WhiteAngela M Wood
Jun 4, 2011·Stroke; a Journal of Cerebral Circulation·Pauline MaillardCharles DeCarli
Jun 16, 2012·AJNR. American Journal of Neuroradiology·P MaillardC DeCarli
Aug 8, 2012·Journal of Alzheimer's Disease : JAD·Rob A R GonsFrank-Erik de Leeuw
Jan 15, 2014·Journal of Clinical and Experimental Neuropsychology·Po Lai YauAntonio Convit
May 2, 2014·Stroke; a Journal of Cerebral Circulation·Pauline MaillardOwen T Carmichael
Jan 8, 2015·Stroke; a Journal of Cerebral Circulation·David S KnopmanUNKNOWN ARIC Neurocognitive Investigators
May 4, 2016·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Melinda C PowerRebecca F Gottesman

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Citations

Nov 9, 2019·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Bonnie Yin Ka LamVincent Chung Tong Mok
Mar 12, 2020·Journal of the American Heart Association·Jingkai WeiGerardo Heiss
Oct 17, 2017·World Journal of Urology·Muhammet Fatih KilincOmer Gokhan Doluoglu
May 28, 2019·Frontiers in Aging Neuroscience·Nathan F JohnsonDavid K Powell
Jul 19, 2019·Frontiers in Aging Neuroscience·Michelle R CauncaClinton B Wright
Aug 11, 2019·Brain Sciences·Farzaneh A Sorond, Philip B Gorelick
May 16, 2020·Frontiers in Aging Neuroscience·Vijay K VenkatramanPatricia M Desmond
Aug 4, 2020·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Pauline H CrollJennifer A Deal
Nov 18, 2018·AJNR. American Journal of Neuroradiology·Y HannawiP A Nyquist
Feb 26, 2019·Journal of Human Hypertension·Ben AllenJ Richard Jennings
Feb 11, 2021·Journal of the International Neuropsychological Society : JINS·Matthew T MeffordApril P Carson
Jan 8, 2021·Frontiers in Endocrinology·Dan-Qiong WangXin Li
Feb 26, 2021·Current Opinion in Neurology·Maria Clara Zanon ZotinPinar Yilmaz
Sep 19, 2017·Metabolism: Clinical and Experimental·Freddy J AlfaroVera Novak
Feb 8, 2018·Metabolism: Clinical and Experimental·Calliope HolingueAdam P Spira
May 29, 2018·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Roza M VlasovaHelen Lavretsky
Apr 16, 2021·Ethnicity & Health·Guilherme M BalbimDavid X Marquez
Jun 16, 2021·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·David A HoageyKristen M Kennedy
May 28, 2021·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·James TingJennifer A Deal

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BETA
blood draw

Software Mentioned

Medi
SAS
STATA
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STAND400
Span

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