Nov 14, 2019

Midlife Atherosclerosis and Development of Alzheimer or Vascular Dementia

Annals of Neurology
Anna-Märta GustavssonOskar Hansson

Abstract

To investigate whether midlife atherosclerosis is associated with different dementia subtypes and related underlying pathologies. Participants comprised the cardiovascular cohort of the Swedish prospective population-based Malmö Diet and Cancer Study (N = 6,103). Carotid plaques and intima media thickness (IMT) were measured at baseline (1991-1994). Dementia incidence until 2014 was obtained from national registers. Diagnoses were reviewed and validated in medical records. In a cognitively unimpaired subcohort (n = 330), β-amyloid42 and tau were quantified in cerebrospinal fluid (CSF), and white matter hyperintensity volume, lacunar infarcts, and cerebral microbleeds were estimated on magnetic resonance imaging (2009-2015). During 20 years of follow-up, 462 individuals developed dementia (mean age at baseline = 57.5 ± 5.9 years, 58% women). Higher IMT in midlife was associated with an increased hazard ratio (HR) of all-cause dementia (adjusted HR = 1.14 [95% confidence interval (CI) = 1.03-1.26]) and vascular dementia (adjusted HR = 1.32 [95% CI = 1.10-1.57]) but not Alzheimer disease (AD) dementia (adjusted HR = 0.95 [95% CI = 0.77-1.17]). Carotid plaques were associated with vascular dementia when assessed as a 3-graded score...Continue Reading

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Citations

Mentioned in this Paper

Intima
Biological Markers
Study
Follow-up
Magnetic Resonance Imaging
Cerebrospinal Fluid
Alzheimer's Disease
Carotid Artery Plaque
Participant
Dementia due to Alzheimer's Disease (Disorder)

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