Midlife Hypertension and Alzheimer's Disease: A Systematic Review and Meta-Analysis

Journal of Alzheimer's Disease : JAD
Matthew J LennonPerminder S Sachdev

Abstract

Hypertension is an established risk factor for stroke and vascular dementia but recent meta-analyses examining the association between Alzheimer's disease (AD) and hypertension have found no significant association. These meta-analyses included short term studies starting in late life which may have obscured the real effect of midlife hypertension. To examine the association of AD with midlife hypertension, by including only studies with a sufficiently long follow up duration. Relevant studies were found by searches of MEDLINE, EMBASE, and PubMed. Study outcomes were grouped by measures of blood pressure and definition of hypertension (e.g., systolic hypertension >  140 mmHg or >  160 mmHg). We assessed pooled effect estimates using random effects models and heterogeneity of pooled estimates through the I2 statistic. Literature search found 3,426 publications of which 7 were eligible studies. There was a significant association between systolic hypertension (>160 mm Hg) and AD (HR 1.25, 95CI 1.06 - 1.47, p = 0.0065). Similarly, for systolic hypertension >  140 mm Hg, there was a smaller but still significant association (HR 1.18, 95CI 1.02 - 1.35, p = 0.021). For diastolic hypertension, all four studies found no significant ass...Continue Reading

References

May 1, 1987·American Journal of Epidemiology·S Greenland
Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
Apr 27, 1996·Lancet·I SkoogA Svanborg
Feb 7, 2001·American Journal of Epidemiology·S S BassukL F Berkman
May 5, 2000·Neurobiology of Aging·L J LaunerR J Havlik
Jul 8, 2000·Stroke; a Journal of Cerebral Circulation·R BarbaT Del Ser
Dec 23, 2000·Dementia and Geriatric Cognitive Disorders·A RuitenbergM M Breteler
May 16, 2003·JAMA : the Journal of the American Medical Association·Aram V ChobanianUNKNOWN National High Blood Pressure Education Program Coordinating Committee
May 11, 2005·Archives of Neurology·Mary GanguliSteven T DeKosky
Jul 12, 2007·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Chun-Ju ChiangChien-Jen Chen
Aug 4, 2007·Neurobiology of Aging·Maria Teresa GentileGiuseppe Lembo
Apr 17, 2008·Epidemiology·Sjoerd M EuserMonique M B Breteler
Jun 20, 2008·Vascular Health and Risk Management·E Duron, Olivier Hanon
Apr 11, 2009·Biological Psychiatry·Louis A ProfennoStephen V Faraone
Jul 14, 2010·Archives of Neurology·Christiane ReitzJosé A Luchsinger
Oct 12, 2010·Archives of Gerontology and Geriatrics·H KimmS H Jee
Oct 22, 2010·Neurobiology of Aging·Daniela CarnevaleLuisa Minghetti
Mar 16, 2011·Journal of General Internal Medicine·Brent C TaylorH Gilbert Welch
Apr 16, 2011·International Journal of Geriatric Psychiatry·Sally I SharpClive Ballard
May 11, 2011·Hypertension·Toshiharu NinomiyaYutaka Kiyohara
Jul 22, 2011·Lancet Neurology·Deborah E Barnes, Kristine Yaffe
Aug 31, 2011·Journal of Alzheimer's Disease : JAD·Jun-Wen GuanQing-Xiu Liu
Apr 5, 2013·JAMA Neurology·Karen M RodrigueDenise C Park
Feb 26, 2015·Alzheimer's Research & Therapy·Javier MarPablo Martínez-Lage
Nov 10, 2015·The New England Journal of Medicine·UNKNOWN SPRINT Research GroupWalter T Ambrosius
Mar 17, 2017·Current Hypertension Reports·Keenan A WalkerRebecca F Gottesman
Apr 12, 2017·JAMA : the Journal of the American Medical Association·Rebecca F GottesmanThomas H Mosley
Oct 6, 2017·Neurology·Paola GilsanzRachel A Whitmer
Nov 10, 2017·Neurology·Emer R McGrathSudha Seshadri
Jul 1, 2008·Dementia & Neuropsychologia·Eliasz Engelhardt, Jerson Laks

❮ Previous
Next ❯

Citations

Jun 21, 2020·Movement Disorders : Official Journal of the Movement Disorder Society·Connie MarrasMichael P McDermott
Aug 18, 2020·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Andrew J AffleckGlenda M Halliday
Nov 24, 2020·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Matthew J LennonPerminder S Sachdev
Jan 6, 2021·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Gabriel A de ErausquinUNKNOWN CNS SARS-CoV-2 Consortium
Jan 15, 2021·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Oliver BrackoChris B Schaffer
Jan 5, 2021·Current Opinion in Psychiatry·Matthew J LennonPerminder S Sachdev
Mar 10, 2021·Molecular and Cellular Biochemistry·Fauzia NazamMd Imtaiyaz Hassan
Mar 16, 2021·Stroke; a Journal of Cerebral Circulation·Ronald M LazarUNKNOWN American Heart Association Stroke Council
Aug 1, 2021·The American Journal of Pathology·Rajesh N Kalaria, Diego Sepulveda-Falla
Aug 31, 2021·Journal of Alzheimer's Disease : JAD·Zhizhong ZhangXinfeng Liu
Sep 20, 2021·Experimental Gerontology·Jane A H Masoli, João Delgado

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.