PMID: 9552168Apr 29, 1998Paper

Midline Fasciclin: a Drosophila Fasciclin-I-related membrane protein localized to the CNS midline cells and trachea

Journal of Neurobiology
S HuS T Crews

Abstract

Drosophila Fasciclin I is the prototype of a family of vertebrate and invertebrate proteins that mediate cell adhesion and signaling. The midline fasciclin gene encodes a second Drosophila member of the Fasciclin I family. Midline Fasciclin largely consists of four 150 amino acid repeats characteristic of the Fasciclin I family of proteins. Immunostaining and biochemical analysis using Midline Fasciclin antibodies indicates that it is a membrane-associated protein, although the sequence does not reveal a transmembrane domain. The gene is expressed in a dynamic fashion during embryogenesis in the blastoderm, central nervous system midline cells, and trachea, suggesting it plays multiple developmental roles. Protein localization studies indicate that Midline Fasciclin is found within cell bodies of midline neurons and glia, and on midline axons. Initial cellular analysis of a midline fasciclin loss-of-function mutation reveals only weak defects in axonogenesis. However, embryos mutant for both midline fasciclin and the abelson nonreceptor tyrosine kinase, show more severe defects in axonogenesis that resemble fasciclin I abelson double mutant phenotypes.

References

Jun 1, 1992·Differentiation; Research in Biological Diversity·D P RomancinoM Di Carlo
Sep 20, 1988·Journal of Molecular Biology·N H Brown, F C Kafatos
Jul 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·P R Langer-SaferD C Ward
Aug 1, 1993·Developmental Biology·A Younossi-Hartenstein, V Hartenstein
Jan 1, 1993·Annual Review of Biochemistry·P T Englund
Jun 18, 1993·Cell·D V VactorC S Goodman
Jan 1, 1996·Annual Review of Neuroscience·C S Goodman

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Citations

Jul 26, 2000·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·W S ReynoldsV M Weis
Jul 15, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·K HoriuchiA Kudo
Feb 7, 2002·The Biochemical Journal·Oliver PolitzSergij Goerdt
Sep 10, 2016·Biochemistry·Marie V LukassenJan J Enghild
Apr 22, 2004·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Tetsuro NakazawaMasashi Yamazaki
Jul 20, 2004·Journal of Cellular Biochemistry·Judith LitvinFayez F Safadi
Sep 24, 2004·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Hironobu SuzukiTakeyasu Maeda
Sep 16, 2003·Journal of Neurobiology·Anita HsounaMark F A VanBerkum
Mar 6, 2010·The Plant Journal : for Cell and Molecular Biology·Colleen P MacMillanSimon G Southerton
Oct 22, 2005·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Judith LitvinRoger Markwald
Apr 2, 2004·Development·Michelle N ArbeitmanBruce S Baker
May 18, 1999·Developmental Biology·T HummelC Klämbt
Jan 18, 2006·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Judith LitvinKenneth Margulies

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