Midluteal Progesterone: A Marker of Treatment Outcomes in Couples With Unexplained Infertility

The Journal of Clinical Endocrinology and Metabolism
Karl R HansenNICHD Reproductive Medicine Network

Abstract

Adequate luteal phase progesterone exposure is necessary to induce endometrial changes required for a successful pregnancy outcome. The relationship between low midluteal progesterone concentration and the outcome of live birth in ovarian stimulation with intrauterine insemination (OS-IUI) treatments is not defined. To determine the level of midluteal progesterone portending a low chance of live birth after OS-IUI in couples with unexplained infertility. Secondary analyses of data from a prospective, randomized, multicenter clinical trial that determined pregnancy outcomes following OS-IUI with clomiphene citrate, letrozole, or gonadotropins for couples with unexplained infertility. Couples (n = 900) underwent 2376 OS-IUI cycles during the Assessment of Multiple Intrauterine Gestations from Ovarian Stimulation clinical trial. Live birth as it relates to midluteal progesterone level and thresholds below which no live births occur by treatment group. Thresholds for non-live birth cycles were similar for clomiphene (14.4 ng/mL) and letrozole (13.1 ng/mL) yet were lower for gonadotropin (4.3 ng/mL) treatments. A midluteal progesterone level >10th percentile specific for each treatment group independently was associated with greater...Continue Reading

Associated Clinical Trials

References

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Sep 24, 2015·The New England Journal of Medicine·Michael P DiamondUNKNOWN NICHD Reproductive Medicine Network
Mar 8, 2016·Fertility and Sterility·Karl R HansenUNKNOWN Eunice Kennedy Shriver National Institute of Child Health and Human Development Reproductive Medicine Network

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Citations

Dec 19, 2018·The Journal of Clinical Endocrinology and Metabolism·Margareta D PisarskaErica T Wang
Dec 4, 2019·Menopause : the Journal of the North American Menopause Society·Nanette SantoroSybil Crawford
Mar 14, 2021·Molecular and Cellular Endocrinology·Sutham SuthapornWalid E Maalouf
Dec 11, 2020·Human Reproduction Update·Stefano PalombaLinda C Giudice
Jan 9, 2022·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Rashid MirMohammad Fahad Ullah

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