Midnight salivary cortisol for the initial diagnosis of Cushing's syndrome of various causes

The Journal of Clinical Endocrinology and Metabolism
Maria YanevaXavier Bertagna

Abstract

We assessed the value of midnight salivary cortisol for the initial diagnosis of Cushing's syndrome. Sixty-three patients with various causes of Cushing's syndrome (37 with Cushing's disease, 17 with adrenal Cushing's syndrome, and nine with ectopic ACTH syndrome) and 54 control subjects with simple obesity were studied. All patients with Cushing's syndrome excreted more than 90 microg urinary free cortisol (UFC)/d (248 nmol/d), and all controls excreted less than 90 microg/d UFC. All patients with Cushing's syndrome had a midnight salivary cortisol concentration above 2.0 ng/ml (5.52 nmol/liter), whereas only three controls did so [2.0 ng/ml (5.52 nmol/liter); 2.05 ng/ml (5.66 nmol/liter); and 3.6 ng/ml (9.96 nmol/liter)]. This cut-off provides a sensitivity of 100% and a specificity of 96%. In patients with Cushing's syndrome, midnight salivary cortisol concentrations were correlated with UFC collected over the same period of time (0800-0800 h). Salivary cortisol measurements taken every 4 h showed a typical lack of circadian variation. The daily measurement of midnight salivary cortisol concentrations for 2 wk or more in five other out-patients (with obvious Cushing's disease, subclinical adrenal Cushing's syndrome, suspecte...Continue Reading

Citations

Feb 24, 2011·Oecologia·Michael J SheriffRudy Boonstra
Sep 1, 2005·Pituitary·Franco ManteroNora M E Albiger
Sep 8, 2010·Reviews in Endocrine & Metabolic Disorders·Ty B Carroll, James W Findling
Aug 26, 2006·Nature Clinical Practice. Endocrinology & Metabolism·Armand Krikorian, David Aron
May 1, 2008·Nature Clinical Practice. Endocrinology & Metabolism·Ty CarrollJames W Findling
Mar 6, 2007·Hormone Research·Semra CetinkayaNursen Yordam
Jul 3, 2009·Neuroimmunomodulation·George P ChrousosEvangelia Charmandari
Jun 20, 2012·Orphanet Journal of Rare Diseases·Frederic CastinettiThierry Brue
Mar 13, 2008·The Journal of Clinical Endocrinology and Metabolism·Lynnette K NiemanVictor M Montori
Jul 16, 2009·The Journal of Clinical Endocrinology and Metabolism·Smita K BaidLynnette K Nieman
Mar 26, 2008·Endocrine Journal·Takao TaniguchiMotozumi Okamoto
Dec 14, 2006·Clinical Chemistry and Laboratory Medicine : CCLM·Michael VogeserChristoph Auernhammer
Oct 27, 2007·Neurosurgical Focus·Bradley A GrossH Hunt Batjer
Sep 3, 2011·European Journal of Endocrinology·Roula Bou KhalilJérôme Bertherat
Jul 21, 2012·European Journal of Endocrinology·Camille BaudryJérôme Bertherat
Jan 16, 2007·European Journal of Endocrinology·F CastinettiT Brue
Jan 8, 2014·European Journal of Endocrinology·R A AlwaniR A Feelders
Mar 18, 2009·European Journal of Endocrinology·Krystallenia I AlexandrakiAshley B Grossman
Jul 16, 2015·Clinical Endocrinology·Urszula AmbroziakTomasz Bednarczuk
Dec 14, 2005·Clinical Endocrinology·Hau LiuElisabeth Ryzen
Aug 20, 2008·Clinical Endocrinology·Estela M L CardosoLiliana N Contreras
Jul 21, 2012·Clinical Endocrinology·Warrick J InderAnthony Russell
May 29, 2009·Clinical Endocrinology·Krystallenia I AlexandrakiAshley B Grossman
Apr 23, 2016·International Journal of Obesity : Journal of the International Association for the Study of Obesity·C YanY Liu
Mar 31, 2016·Clinical Endocrinology·Charlotte SteffensenJens Otto L Jørgensen
Dec 2, 2008·La Presse médicale·Laurence GuignatJérôme Bertherat
Feb 10, 2007·Journal of Pediatric and Adolescent Gynecology·Evaldo dos SantosMarcos F Silva de Sá
Jan 30, 2008·La Revue de médecine interne·C RosalesM-L Raffin-Sanson
May 6, 2009·Clinical Biochemistry·Rosalba GattiElio F De Palo
Jan 23, 2008·Arquivos brasileiros de endocrinologia e metabologia·Margaret de Castro, Ayrton C Moreira
Jan 23, 2008·Arquivos brasileiros de endocrinologia e metabologia·Lucio VilarOscar D Bruno
Jan 23, 2008·Arquivos brasileiros de endocrinologia e metabologia·Li F ChanMartin O Savage
Jan 23, 2008·Arquivos brasileiros de endocrinologia e metabologia·Nora Maria Elvira AlbigerFranco Mantero
Jan 23, 2008·Arquivos brasileiros de endocrinologia e metabologia·Lucio VilarClaudio E Kater
Dec 25, 2007·Arquivos brasileiros de endocrinologia e metabologia·Maria Silvia S CaetanoClaudio E Kater
Dec 7, 2007·Clinica Chimica Acta; International Journal of Clinical Chemistry·Giuseppe ReimondoMassimo Terzolo
May 16, 2006·Lancet·John Newell-PriceLynnette K Nieman
Dec 23, 2016·Clinica Chimica Acta; International Journal of Clinical Chemistry·P M O'SheaM Fitzgibbon

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Clinical Endocrinology and Metabolism
Dimitris A PapanicolaouLynnette K Nieman
Clinica Chimica Acta; International Journal of Clinical Chemistry
W W LutholdB L Wajchenberg
The Journal of Clinical Endocrinology and Metabolism
James W FindlingDavid C Aron
© 2022 Meta ULC. All rights reserved