Midodrine. A review of its pharmacological properties and therapeutic use in orthostatic hypotension and secondary hypotensive disorders.

Drugs
D McTavish, K L Goa

Abstract

Midodrine, a peripheral alpha-adrenergic agonist, finds use in the clinical management of patients with orthostatic hypotension or hypotension secondary to other clinical conditions or drug therapies. Midodrine is almost completely absorbed after oral administration and undergoes enzymatic hydrolysis to form its pharmacologically active metabolite, de-glymidodrine. In patients with refractory orthostatic hypotension oral midodrine increases standing blood pressure and improves symptoms of orthostatism, such as weakness, syncope, blurred vision and fatigue, without any associated cardiac stimulation. Comparative studies have shown midodrine to be clinically at least as effective as other sympathomimetic agents (norfenefrine, etilefrine, dimetofrine and ephedrine) and dihydroergotamine in this regard. Additionally, midodrine appears to cause less frequent and severe adverse effects associated with alpha-receptor agonism such as piloerection and urinary hesitancy. The most commonly experienced adverse effects--piloerector reactions, gastrointestinal disorders, and cardiovascular complaints--are generally mild and can be controlled by reducing the dosage of midodrine. Thus, midodrine is at least as useful as other currently availab...Continue Reading

Citations

May 18, 2001·Journal of Applied Physiology·C D RamsdellR J Cohen
Jul 16, 2002·The International Journal of Artificial Organs·P PassadakisD G Oreopoulos
Oct 7, 2004·The Annals of Pharmacotherapy·Tim M Young, Christopher J Mathias
Apr 12, 2005·Journal of Cardiovascular Pharmacology and Therapeutics·Sanjiv Sharma, Brijesh Bhambi
Apr 3, 2009·The Journal of Physiological Sciences : JPS·Stefan DuschekGustavo A Reyes del Paso
Mar 10, 2016·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Ahmed ElgebalyAhmed Negida
Jul 16, 2016·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·L Y WongG K Isbister
Apr 23, 2016·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists
Sep 30, 1993·The New England Journal of Medicine·D B Calne
Feb 21, 2007·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Kiichiro FujisakiMitsuo Iida
Jul 4, 2016·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·William SmithPatrick Martin
Mar 7, 2018·Movement Disorders : Official Journal of the Movement Disorder Society·Jose-Alberto Palma, Horacio Kaufmann
Apr 4, 2018·Critical Care Medicine·Mahrukh S RizviOgnjen Gajic
Nov 26, 2019·Cardiology in Review·Pravin Khemani, Ali A Mehdirad
Apr 11, 2020·Journal of Clinical and Translational Hepatology·Anand V KulkarniD Nageshwar Reddy
Jan 1, 1997·Journal of Cardiovascular Electrophysiology·J SraM Akhtar
Aug 9, 2003·Expert Opinion on Drug Safety·Mark A Perazella
May 29, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P AngeliA Gatta
Oct 1, 1995·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·C Ward, R A Kenny
May 9, 2002·Hospital Medicine·M Abu Nasar, Shaku Murty
May 23, 2008·Journal of Cardiovascular Pharmacology and Therapeutics·Sanjiv SharmaBrijesh Bhambi
Oct 3, 2009·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Gianfranco ParatiPaolo Castiglioni
Mar 6, 2007·American Journal of Physiology. Heart and Circulatory Physiology·A LippP A Low
Sep 10, 2014·Journal of General Internal Medicine·W SingerP A Low
Dec 25, 2016·Pharmacological Reviews·Italo Biaggioni
Aug 28, 2019·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Jose-Alberto PalmaHoracio Kaufmann
Oct 2, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P AngeliA Gatta
Mar 1, 1995·Diabetic Medicine : a Journal of the British Diabetic Association·T S Purewal, P J Watkins
Dec 12, 2001·Pediatrics International : Official Journal of the Japan Pediatric Society·K TorigoeH Endo
Dec 22, 2006·Expert Review of Neurotherapeutics·Theresa A ZesiewiczRobert A Hauser
Apr 29, 2003·Pacing and Clinical Electrophysiology : PACE·Blair P GrubbYousuf Kanjwal
Mar 19, 2014·Journal of Neurotrauma·Aaron A PhillipsDarren E R Warburton
Sep 10, 2019·American Journal of Therapeutics·Nikhil CordeiroYizhak Kupfer
Aug 8, 2009·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Stefan DuschekGustavo A Reyes del Paso
Jul 18, 2017·Movement Disorders Clinical Practice·Jose-Alberto Palma, Horacio Kaufmann
Nov 18, 2019·Clinics in Geriatric Medicine·Jose-Alberto Palma, Horacio Kaufmann

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Cardiovascular & Hematological Disorders Drug Targets
Simona MauleFranco Veglio
American Family Physician
Jeffrey B LanierEmily C Clay
American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions
Maxime Lamarre-Cliche
© 2022 Meta ULC. All rights reserved