Midodrine improves orgasm in spinal cord-injured men: the effects of autonomic stimulation

The Journal of Sexual Medicine
Jean Marc SolerE Chartier-Kastler

Abstract

Orgasm is less frequent in men with spinal cord injury (SCI) than in able-bodied subjects, and is poorly understood. To assess the effect of autonomic stimulation on orgasm in SCI men using midodrine, an alpha1-adrenergic agonist agent. Penile vibratory stimulation (PVS) was performed in 158 SCI men on midodrine as part of a treatment for anejaculation, after they failed a baseline PVS. A maximum of four trials were performed, weekly, with increasing doses of midodrine. The presence and type of ejaculation, orgasm experiences, and cardiovascular data were collected. Ejaculation either antegrade or retrograde was obtained in 102 SCI men (65%). Orgasm without ejaculation was reported by 14 patients (9%) on baseline PVS. Ninety-three patients (59%) experienced orgasm during PVS on midodrine. Orgasm was significantly related to the presence of ejaculation in 86 patients (84%), and more strikingly to antegrade ejaculation (pure or mixed with retrograde), i.e., in 98% of 70 patients. Orgasm was significantly more frequent in patients with upper motor neuron and incomplete lesions who present somatic responses during PVS. There was no effect of the presence of psychogenic erection. There was a significant increase in both systolic and...Continue Reading

References

Jun 1, 1993·Archives of Sexual Behavior·C J AlexanderT W Findley
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Jan 21, 2006·The Journal of Sexual Medicine·Chris G McMahonZhong Cheng Xin
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Sep 18, 2007·The Journal of Urology·J M SolerE Chartier-Kastler

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Citations

Jan 5, 2012·Journal of Assisted Reproduction and Genetics·Yi QiuMei-Hua Zhang
Mar 17, 2009·The Journal of Sexual Medicine·Brandt YoungKevin McKenna
Jul 9, 2013·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·B Perrouin-VerbeF Giuliano
Jun 30, 2010·The Journal of Sexual Medicine·Waguih William IshakYekaterina Bakhta
Apr 22, 2011·BJU International·Frédérique CourtoisIsabelle Côté
Aug 31, 2010·Archives of Physical Medicine and Rehabilitation·Jill M WechtWilliam A Bauman
Apr 13, 2018·Spinal Cord Series and Cases·J M SolerG Amarenco
Dec 21, 2017·Spinal Cord·Marcalee Alexander, Lesley Marson
Feb 10, 2018·Spinal Cord Series and Cases·J G PrevinaireA McLain
Oct 19, 2017·NeuroRehabilitation·Marcalee Sipski AlexanderMindy Lipson Aisen
Jan 18, 2018·Topics in Spinal Cord Injury Rehabilitation·Marcalee AlexanderMitchell Tepper
Jul 4, 2018·Spinal Cord·Jean-Marc SolerJean-Gabriel Previnaire
Jun 28, 2018·World Journal of Urology·J T StoffelS Elliott

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