Midpregnancy serum C-peptide concentration and subsequent pregnancy-induced hypertension

Diabetes Care
I YasuhiM W Carpenter

Abstract

To test the hypothesis that elevated midpregnancy serum insulin (IRI) and C-peptide (CP) concentrations are associated with later development of pregnancy-induced hypertension (PIH), independent of prepregnancy obesity and midpregnancy blood pressure. In this prospective study, a cohort of normotensive women, ages > or = years performed a 50-g glucose challenge test at 24-30 weeks' gestational age. Blood samples were collected after an overnight fast and 1 h after glucose ingestion. Serum IRI and CP concentrations were measured in each sample. Maternal height, blood pressure and proteinuria were measured at the time of glucose challenge testing and after 36 weeks' gestational age. Of 320 subjects enrolled 44 women (13.8%) had subsequent PIH. Crude odds ratios (ORs) for devevelopment of PIH associated with each 1 U rise in log fasting IRI, log lasting CP. and glucosed-induced increase in CP (expressed as log [postprandial CP/fasting CP]) were 2.0 (95% CI 1.3-3.3), 1.8 (CI 1.2-2.7), and 2.3 (CI 1.1-4.9) respectively. After controlling for prepregnancy BMI, gestational age, and midpregnancy mean arterial pressure, adjusted ORs corresponding to log fastig IRI and CP for the development of PIH were 1.3 (95% CI 0.7-2.3) and 1.7 (CI 1...Continue Reading

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Citations

Mar 20, 2003·Current Diabetes Reports·Gyula Tamás, Zsuzsa Kerényi
Jul 31, 2009·Current Diabetes Reports·Dimitrios S MastrogiannisCarol J Homko
Jun 17, 2009·Seminars in Reproductive Medicine·Rhonda Bentley-Lewis
Jul 13, 2012·Clinical and Experimental Hypertension : CHE·Hatice Ender SoydincIbrahim Sari
Jun 19, 2002·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Herbert ValensiseDomenico Arduini

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