Abstract
To test the hypothesis that elevated midpregnancy serum insulin (IRI) and C-peptide (CP) concentrations are associated with later development of pregnancy-induced hypertension (PIH), independent of prepregnancy obesity and midpregnancy blood pressure. In this prospective study, a cohort of normotensive women, ages > or = years performed a 50-g glucose challenge test at 24-30 weeks' gestational age. Blood samples were collected after an overnight fast and 1 h after glucose ingestion. Serum IRI and CP concentrations were measured in each sample. Maternal height, blood pressure and proteinuria were measured at the time of glucose challenge testing and after 36 weeks' gestational age. Of 320 subjects enrolled 44 women (13.8%) had subsequent PIH. Crude odds ratios (ORs) for devevelopment of PIH associated with each 1 U rise in log fasting IRI, log lasting CP. and glucosed-induced increase in CP (expressed as log [postprandial CP/fasting CP]) were 2.0 (95% CI 1.3-3.3), 1.8 (CI 1.2-2.7), and 2.3 (CI 1.1-4.9) respectively. After controlling for prepregnancy BMI, gestational age, and midpregnancy mean arterial pressure, adjusted ORs corresponding to log fastig IRI and CP for the development of PIH were 1.3 (95% CI 0.7-2.3) and 1.7 (CI 1...Continue Reading
References
Jan 1, 1990·Diabetes·R W BergstromW Y Fujimoto
Feb 1, 1990·Metabolism: Clinical and Experimental·T PollareC Berne
Aug 1, 1988·American Journal of Obstetrics and Gynecology·W A BaumanO Langer
Dec 1, 1988·Diabetes·G M Reaven
Aug 6, 1987·The New England Journal of Medicine·E FerranniniS Bevilacqua
May 1, 1984·Diabetes·K S Polonsky, A H Rubenstein
Jan 1, 1995·American Journal of Hypertension·J R SowersR J Sokol
Mar 1, 1995·Obstetrics and Gynecology·R KaajaO Ylikorkala
Nov 1, 1993·Diabetes·S E KahnJ P Palmer
Jan 1, 1993·The American Journal of Physiology·P M CatalanoE A Sims
Nov 1, 1995·Acta Obstetricia Et Gynecologica Scandinavica·L S JónsdóttirN Sigfússon
Nov 1, 1996·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·T HamasakiT Ishimaru
May 1, 1997·The Journal of Maternal-fetal Medicine·F J CioffiV A Rifici
Jun 22, 1999·Human Reproduction·A CarusoG Paradisi
Jul 2, 1999·Diabetes Care·K MatsumotoY Tominaga
Jul 27, 1999·Metabolism: Clinical and Experimental·R KaajaO Ylikorkala
Sep 28, 2000·Human Reproduction·G GennarelliH Lithell
Citations
Mar 20, 2003·Current Diabetes Reports·Gyula Tamás, Zsuzsa Kerényi
Jul 31, 2009·Current Diabetes Reports·Dimitrios S MastrogiannisCarol J Homko
Apr 15, 2011·Cardiovascular Diabetology·Martin AndreasAlexandra Kautzky-Willer
Jun 17, 2009·Seminars in Reproductive Medicine·Rhonda Bentley-Lewis
Dec 17, 2010·Gynecologic and Obstetric Investigation·Attila Kun
Jul 13, 2012·Clinical and Experimental Hypertension : CHE·Hatice Ender SoydincIbrahim Sari
Jun 19, 2002·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Herbert ValensiseDomenico Arduini